Drug resistance and genotypes of Mycobacterium tuberculosis in Datong area

Central Plains Medical Journal Pub Date : 2020-03-10 DOI:10.3760/CMA.J.ISSN.1674-4756.2020.05.012

C. Wei, Yueping Wang, Shuping Li

{"title":"Drug resistance and genotypes of Mycobacterium tuberculosis in Datong area","authors":"C. Wei, Yueping Wang, Shuping Li","doi":"10.3760/CMA.J.ISSN.1674-4756.2020.05.012","DOIUrl":null,"url":null,"abstract":"Objective \nTo analyze the drug resistance and genotypes of Mycobacterium tuberculosis in Datong area. \n \n \nMethods \nA total of 120 strains of Mycobacterium tuberculosis isolated in the Fourth People’s Hospital of Datong from January 2018 to January 2019 were collected. Drug sensitivity tests were carried out by proportional method. The genotypes of 120 strains of Mycobacterium tuberculosis were analyzed by polymerase chain reaction (PCR) and spacer oligonucleotide typing (spoligotyping). \n \n \nResults \nOf the 120 strains of Mycobacterium tuberculosis, 78 strains were sensitive to isoniazid, rifampicin, ethambutol and streptomycin, and 42 strains were resistant to these drugs, with the drug resistance rate of 35.00%. Eighty-three strains (69.17%) were Beijing genotype, 37 strains (30.83%) were non-Beijing genotype. Gender, age, affected lung, history of tuberculosis treatment, strain source, genotyping had no significant effect on drug resistance or genotype of tuberculosis strains (P>0.05). \n \n \nConclusions \nBeijing genotype Mycobacterium tuberculosis is a major epidemic strain in Datong region, and no significant correlation is found between drug resistance and genotype of Mycobacterium tuberculosis in Datong area. \n \n \nKey words: \nMycobacterium tuberculosis; Drug resistance; Genotype; Analysis","PeriodicalId":9667,"journal":{"name":"Central Plains Medical Journal","volume":"11 1","pages":"41-43"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central Plains Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1674-4756.2020.05.012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To analyze the drug resistance and genotypes of Mycobacterium tuberculosis in Datong area. Methods A total of 120 strains of Mycobacterium tuberculosis isolated in the Fourth People’s Hospital of Datong from January 2018 to January 2019 were collected. Drug sensitivity tests were carried out by proportional method. The genotypes of 120 strains of Mycobacterium tuberculosis were analyzed by polymerase chain reaction (PCR) and spacer oligonucleotide typing (spoligotyping). Results Of the 120 strains of Mycobacterium tuberculosis, 78 strains were sensitive to isoniazid, rifampicin, ethambutol and streptomycin, and 42 strains were resistant to these drugs, with the drug resistance rate of 35.00%. Eighty-three strains (69.17%) were Beijing genotype, 37 strains (30.83%) were non-Beijing genotype. Gender, age, affected lung, history of tuberculosis treatment, strain source, genotyping had no significant effect on drug resistance or genotype of tuberculosis strains (P>0.05). Conclusions Beijing genotype Mycobacterium tuberculosis is a major epidemic strain in Datong region, and no significant correlation is found between drug resistance and genotype of Mycobacterium tuberculosis in Datong area. Key words: Mycobacterium tuberculosis; Drug resistance; Genotype; Analysis

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

大同地区结核分枝杆菌耐药性及基因型分析

目的分析大同地区结核分枝杆菌的耐药情况及基因型。方法收集2018年1月至2019年1月在大同市第四人民医院分离的120株结核分枝杆菌。采用比例法进行药敏试验。采用聚合酶链反应(PCR)和间隔寡核苷酸分型(spoligotyping)对120株结核分枝杆菌进行基因型分析。结果120株结核分枝杆菌中，异烟肼、利福平、乙胺丁醇、链霉素敏感78株，耐药42株，耐药率为35.00%;北京基因型83株(69.17%)，非北京基因型37株(30.83%)。性别、年龄、患肺、结核治疗史、菌株来源、基因分型对结核菌株耐药和基因分型均无显著影响(P>0.05)。结论北京基因型结核分枝杆菌是大同地区主要流行菌株，大同地区结核分枝杆菌耐药与基因型无显著相关性。关键词:结核分枝杆菌;耐药;基因型;分析

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Central Plains Medical Journal

自引率

0.00%

发文量