REGULATION OF BIOCATALYTIC PROPERTIES OF RHODOSPIRILLUM RUBRUM L-ASPARAGINASE BY THE FORMATION OF ENZYME CONJUGATES WITH POLYCATIONS

D. Zhdanov, N. Sokolov, E. Kudryashova
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Abstract

Covalent conjugates of asparaginase with copolymers of chitosan-PEG, chitosan-glycol and chitosan-PEI were obtained and their antitumor activity on human chronic myeloma leukemia K-562 cells was determined.
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红红螺旋藻l -天冬酰胺酶生物催化性能的调控
研究了壳聚糖- peg、壳聚糖-乙二醇和壳聚糖- pei共聚物对天冬酰胺酶的共价偶联物,并测定了它们对人慢性骨髓瘤白血病K-562细胞的抗肿瘤活性。
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