Megan Kitson, Heather N. Sheppard, Joanne C. Morris, N. Howarth, A. Kraft
{"title":"A Low-Cost Method for Measuring the Permeability of a Pharmaceutical Drug in a Diffusion Cell","authors":"Megan Kitson, Heather N. Sheppard, Joanne C. Morris, N. Howarth, A. Kraft","doi":"10.1333/S00897142584A","DOIUrl":null,"url":null,"abstract":"A low-cost, in vitro laboratory experiment has been developed that mimics the absorption of a pharmaceutical drug in the body. It allows undergraduate chemistry students to gain experience in the measurement of drug permeability coefficients, a key indicator used by the pharmaceutical industry to identify the ease of absorption of any new drug candidate. The experiment requires a diffusion cell, coated membrane, peristaltic pump and UV-Vis spectrophotometer. The method has been validated by determining the permeability coefficients for a selection of acidic, basic and non-ionizable drugs. Using this assay, it is possible to classify drugs as exhibiting high or low permeability in a fast, facile and reliable manner.","PeriodicalId":22396,"journal":{"name":"The Chemical Educator","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Chemical Educator","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1333/S00897142584A","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
A low-cost, in vitro laboratory experiment has been developed that mimics the absorption of a pharmaceutical drug in the body. It allows undergraduate chemistry students to gain experience in the measurement of drug permeability coefficients, a key indicator used by the pharmaceutical industry to identify the ease of absorption of any new drug candidate. The experiment requires a diffusion cell, coated membrane, peristaltic pump and UV-Vis spectrophotometer. The method has been validated by determining the permeability coefficients for a selection of acidic, basic and non-ionizable drugs. Using this assay, it is possible to classify drugs as exhibiting high or low permeability in a fast, facile and reliable manner.
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