Association between the sinus of Valsalva height and biometric parameters in patients with Marfan syndrome associated with aortic root aneurysm

Abstract

Patients with Marfan syndrome and aortic root aneurysm require pre-surgical analysis of aortic root geometry for aortic reconstruction. The aim of this study is to perform the morphometric analysis of the sinus of Valsalva height and correlation between the former, age, weight, height, body mass index (BMI), and body surface area (BSA) in patients with Marfan syndrome and aortic root aneurysm. Data from 34 patients (28 men, 6 women) with Marfan syndrome and an ascending aortic diameter exceeding 45 cm were obtained using computed tomography angiography. Gender-based differences were observed in the height of the left aortic sinus – by 47.23% (36.47±12.48 mm in men against 24.77±4.26 mm in women, р=0.0003). In men, a strong direct correlation has been identified between height and the right aortic sinus height (r=+0.75, р<0.0001), the posterior aortic sinus height (r=+0.71, р<0.0001), and the left aortic sinus height (r=+0.75, р<0.0001). Moderate reverse correlation has been discovered between the sinus of Valsalva height and BMI. No correlations have been identified between weight, BSA and the sinus of Valsalva height (р>0.05). In women, a strong direct correlation (Pearson) has been identified between age and the right aortic sinus height (r=+0.84, p=0.04), between weight and the left aortic sinus (r=+0.73, p=0.04) and between BSA and the left aortic sinus (r=+0.73, р=0.04). Aortic sinus height in men increases with height and decreases with higher BMI and age. Weight and BSA do not affect the sinus of Valsalva height. In women, the sinus of Valsalva height is impacted by age, weight and BSA.