Research on efficient synthetic method of β- and δ-carbolines using a Copper catalyst

Abstract

Methodology for synthesizing of β- and δ-carboline via two steps reaction from 2,3-dibromopyridine and 3,4-dibromopyridine. The intermediate was prepared from the substrate with o-bromophenylboronic acid via site-selective Suzuki-Myaura reaction, then, the final products were obtained by double C-N coupling via the Ulmann reaction of the intermediate with the corresponding amine with copper catalyst.