Moisturizing Lotion Formulation on Tropical Skin based on Cananga Oil (Cananga odorata), Kaffir Lime Oil (Citrus hystrix DC) and Patchouli Oil (Pogostemon cablin) as a Bioactive

Abstract

: Indonesia is a tropical country with an average room temperature 37 o C and humidity in each region are varies. These conditions make the skin sweat so that the skin loses water. If it left unchecked, it can cause a variety of skin diseases. Proper moisturizer can reduce and prevent damage to the skin. Essential oils have specific bioactive contents such as an antioxidant, anti-inflammatory and antibacterial properties. Previous research has shown that Cananga oil has high anti-bacterial and antioxidant activity (close to 80% ascorbic acid). Citronellal compounds in kaffir lime oil can be used as an antimicrobial and anti-inflammatory. In addition to essential oils, sunflower seed oil is used as a carrier oil to prevent irritation due to high concentrations of essential oils. Sunflower Oil contains oleic and linoleic acids which can improve water absorption in the skin as well as antioxidants. Research on the process of extracting essential oils has been widely carried out, but the use of essential oils that have bioactive content has not been done much. Lotion is one of skin care that is commonly used on the skin. This research aims to get the best formulation in making cananga oil, kaffir lime oil, patchouli oil based lotion which have high antioxidant activity, high hydration effect and good consistency. Essential oils as active ingredients are added with various compositions then formulated and tested in vivo and in vitro. The urgency of this research is to get a lotion formulation from essential ingredients suitable for the skin of the tropics so that later it can be eliminated and support UB especially in welcoming PTNBH. The results showed that the lotion is stabled after stability testing for 7 cycles of cooling 4oC and heating 40 o C. The pH test results also indicate that the lotion has a pH between 7.05 - 7.95 which is in accordance with SNI standards. The lotion spread test shows that the greater the load given, the greater the spread diameter of the lotion. The best lotion dispersion is found in Formula V4, W2 with a bio active concentration: base lotion of 1:11,5. For the results of in vitro testing of mice, it was found that there is no lotion formula that causes allergies.