Implementation of improved postoperative care decreases the mortalit1y rate of operated mice after an abundant 6-hydroxy dopamine lesion of nigrostriatal dopaminergic neurons
Sini K. Koski, Sakari Leino, S. Rannanpää, O. Salminen
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引用次数: 2
Abstract
Various ways exist to establish rodent models of Parkinson’s disease, a neurodegenerative motor disorder caused by the death of dopaminergic neurons that have their cell bodies in the substantia nigra pars compacta (SNc) and project into the dorsal striatum. Neurodegeneration and motor symptoms of Parkinson’s disease can be mimicked in animals by degenerating these nigrostriatal neurons with different neurotoxins, administered either systemically or intracranially, or by genetic manipulations (Bové & Perier, 2012). Importantly, different methods can cause difImplementation of improved postoperative care decreases the mortality rate of operated mice after an abundant 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons
期刊介绍：
The Scandinavian Journal of Laboratory Animal Science (SJLAS), published by Scand-LAS, is a longstanding international journal advancing knowledge about comparative medicine and laboratory animal science and welfare through the publication of peer-reviewed articles about animal models, animal biology, laboratory animal medicine, laboratory animal pathology, animal behaviour, animal biotechnology and related topics. Articles include technical reports and reviews about basic and applied laboratory investigations, clinical investigations, and case studies, as well as informed and thoughtful opinions relevant to the humane care and use of laboratory animals. SJLAS also includes advertisements from all major suppliers of laboratory animals, caging systems, food, bedding and other relevant equipment for laboratory animal housing, husbandry and experimentation. In addition it includes news from the Scand-LAS Association, as well as an updated comprehensive list of upcoming relevant meetings, conferences and symposia.
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