THROMBOLYTIC THERAPY IN PEDIATRIC PRACTICE (PART 1)

Abstract

Thromboses in children represent the serious pathology that can lead to disability and even death of a pediatric patient. At certain localizations of thrombosis, the most rapid restoration of vascular patency (reperfusion) becomes prognostically significant. The most accessible method for reperfusion is drug therapy, in which a drug is injected into the patient's blood, which in its turn significantly accelerates the process of fibrinolysis, i.e., thrombolytic therapy (TT). The purpose of this bibliographical review was to familiarize physicians, especially pediatricians with the place of TT in modern clinical practice. The article represents bibliographical review of published works for over 50 years (since 1966). Authors have used both domestic Russian resources and the PUBMED database. Articles were selected based on the relevance. Statistical analysis was not performed. A review and analysis of bibliographical data on the modern use of TT in pediatric practice is presented. Preference was given to the most modern publications containing analytical information with full text available both pro bono and online. Authors emphasize pediatric practitioners’ attention on the fact that TT at the current level of knowledge is a fairly effective and predictable method for rapid reperfusion.