Takeo Takeda, Masahiro Ogawa, J. Kitamoto, Takahiro Kyoya, M. Terada
{"title":"High Glucose Enhances Skin Sensitizer-induced NRF2 Activation In Vitro","authors":"Takeo Takeda, Masahiro Ogawa, J. Kitamoto, Takahiro Kyoya, M. Terada","doi":"10.2174/1874340402107010008","DOIUrl":null,"url":null,"abstract":"Hyperglycemia, blood glucose levels above 2.0 g/L, is one of the major pathophysiological factors causing late complications in diabetes [1, 2]. Reactive Oxygen Species (ROS) are increased by hyperglycemia [3]. Oxidative damage in individual cells may reach a sufficient threshold to cause DNA strand breaks and induce cell death [4]. Therefore, hyperglycemia-induced oxidative stress is one of the responsible factors for the pathology of diabetic complications.","PeriodicalId":22859,"journal":{"name":"The Open Toxicology Journal","volume":"5 1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Toxicology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874340402107010008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Hyperglycemia, blood glucose levels above 2.0 g/L, is one of the major pathophysiological factors causing late complications in diabetes [1, 2]. Reactive Oxygen Species (ROS) are increased by hyperglycemia [3]. Oxidative damage in individual cells may reach a sufficient threshold to cause DNA strand breaks and induce cell death [4]. Therefore, hyperglycemia-induced oxidative stress is one of the responsible factors for the pathology of diabetic complications.
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