Preparation and Evaluation of Directly Compressible Tablets of Ibuprofen Crystals

Abstract

The goalof present studywas to prepare the directly compressible tablets of Ibuprofen crystals prepared by crystallization technique using saccharin sodium as an excipient. The prepared tabletswere evaluatedfor the improvement in drug release of Ibuprofenas compared to the pure drug. The crystal formation of Ibuprofen lead to improve the compressibility and mechanical strength of thedrug which can be easily converted to directlycompressible tablets. The In-vitro dissolution profiledemonstrates 3.96fold incrementin the drug release rate from tablets of Ibuprofen crystals compared to the pure drug after one hour. The characterization was done byPowder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) Study of Ibuprofen treated crystals illustrates the improvement in manufacturabilityand pharmacotechnical parameters of the drug.©2022iGlobal Research and PublishingFoundation. All rights reserved.