Synthesis and Evaluation Biological Activity of Six Oxapentacyclo Derivatives on Gram Negative and Gram Postive Bacteria

Abstract

There are drugs such as cephalosporin, penicillins, aminoglycosides, quinolones for the treatment of infectious diseases; however, some of these drugs can produce bacterial resistance. This research aimed to synthesize six oxapentacyclo derivatives to evaluate their biological activity against some Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Streptococcus pneumoniae using the minimum inhibitory concentration method. The results showed that the methods used in this study produce a good yield of each product. Furthermore, the chemical structure of compounds 2 to 7 was determined using 1H and 13C NMR spectroscopic techniques. Other data showed that only compounds 3 and 5 decreased the growth bacterial of Garam-negative and Gram-positive bacteria; these data suggest that compounds 3 and 5 could be considered good antibacterial agents against infectious diseases produced by Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Streptococcus pneumoniae.