The role of probiotics in lowering severity of symptoms in urban women with functional constipation: A randomized double-blind controlled trial

M. Abdullah, H. Maulahela, A. P. Utari, P. Kusumo, A. Soebandrio, I. Surono, D. Makmun
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引用次数: 1

Abstract

Functional constipation is one of the most common gastrointestinal disorders worldwide, especially in women. Probiotic consumption is commonly used to alleviate symptoms of constipation but the mechanism and the result remain unclear. Hence, this study was conducted to assess the effect of probiotics on constipation symptoms using PAC-SYM© (Patient Assessment of Constipation Symptoms) questionnaire. This was a randomized double-blind controlled trial (RCT) study, consisting of 73 subjects of urban women with functional constipation. This study compared three weeks of probiotic (Lactobacillus plantarum IS 10506) administration with placebo and evaluated improvements in PAC-SYM© scores before and after intervention. The subjects were divided into two groups, probiotics group (n = 34) and placebo group (n = 39), then were compared for their mean difference of PAC-SYM© scores. Our study suggested improvements of symptoms after three weeks of probiotic administration, as shown by the total score of PAC-SYM© (mean difference 7.65, 95% CI 3.1-12.20; p=0.001) along with three domains of PAC-SYM©, abdominal symptoms (mean difference 3.0, 95% CI 1.3-4.7; p=0.001), rectal symptoms (mean difference 1.62, 95% CI 0.12-3.13; p=0.034) and stool symptoms (mean difference 3.02, 95% CI 0.58-5.45; p=0.016. Probiotics was superior than placebo in improvements of constipation symptoms in urban women with functional constipation.Functional constipation is one of the most common gastrointestinal disorders worldwide, especially in women. Probiotic consumption is commonly used to alleviate symptoms of constipation but the mechanism and the result remain unclear. Hence, this study was conducted to assess the effect of probiotics on constipation symptoms using PAC-SYM© (Patient Assessment of Constipation Symptoms) questionnaire. This was a randomized double-blind controlled trial (RCT) study, consisting of 73 subjects of urban women with functional constipation. This study compared three weeks of probiotic (Lactobacillus plantarum IS 10506) administration with placebo and evaluated improvements in PAC-SYM© scores before and after intervention. The subjects were divided into two groups, probiotics group (n = 34) and placebo group (n = 39), then were compared for their mean difference of PAC-SYM© scores. Our study suggested improvements of symptoms after three weeks of probiotic administration, as shown by the total score of PAC-SYM© (m...
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益生菌在降低城市女性功能性便秘症状严重程度中的作用:一项随机双盲对照试验
功能性便秘是世界上最常见的胃肠疾病之一,尤其是女性。食用益生菌通常用于缓解便秘症状,但其机制和结果尚不清楚。因此,本研究采用PAC-SYM©(患者便秘症状评估)问卷评估益生菌对便秘症状的影响。这是一项随机双盲对照试验(RCT)研究,包括73名患有功能性便秘的城市女性。本研究比较了三周的益生菌(植物乳杆菌IS 10506)治疗和安慰剂治疗,并评估了干预前后PAC-SYM©评分的改善情况。将受试者分为两组,益生菌组(n = 34)和安慰剂组(n = 39),比较其PAC-SYM©评分的平均差异。我们的研究表明,服用益生菌三周后症状有所改善,如PAC-SYM©总分(平均差值7.65,95% CI 3.1-12.20;p=0.001)以及PAC-SYM©的三个域、腹部症状(平均差异3.0,95% CI 1.3-4.7;p=0.001),直肠症状(平均差异1.62,95% CI 0.12-3.13;p=0.034)和大便症状(平均差异3.02,95% CI 0.58-5.45;p = 0.016。益生菌在改善功能性便秘的城市妇女便秘症状方面优于安慰剂。功能性便秘是世界上最常见的胃肠疾病之一,尤其是女性。食用益生菌通常用于缓解便秘症状,但其机制和结果尚不清楚。因此,本研究采用PAC-SYM©(患者便秘症状评估)问卷评估益生菌对便秘症状的影响。这是一项随机双盲对照试验(RCT)研究,包括73名患有功能性便秘的城市女性。本研究比较了三周的益生菌(植物乳杆菌IS 10506)治疗和安慰剂治疗,并评估了干预前后PAC-SYM©评分的改善情况。将受试者分为两组,益生菌组(n = 34)和安慰剂组(n = 39),比较其PAC-SYM©评分的平均差异。我们的研究表明,服用益生菌三周后症状有所改善,如PAC-SYM总分©(m…
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