Research Progress on mechanism of inhibition of phagosome-lysosome formation by Mycobacterium tuberculosis

Abstract

Phagocytosis is indispensable in the process of degradation, presentation, activation of adaptive immune response and clearance of Mycobacterium tuberculosis.In the process of phagocytosis, the development of phagosome vesicles into mature phagosomes requires a series of processes including lysosomal fusion, lowering the pH in the cavity, activation of enzymes, and finally destroying phagocytic microorganisms.Phagocytes, such as monocytes and macrophages, participate in host defense by forming phagolysosomes, while Mycobacterium tuberculosis exhibits a significant ability to block the maturation of phagosomes, thus escaping the host defenses and eventually leading to the disease.This article reviews the research progress on the mechanism of inhibition of phagocyte-lysosome formation by Mycobacterium tuberculosis, in order to provide a reference for the early control of disease and the development of new drugs. Key words: Tuberculosis; Mycobacterium tuberculosis; Phagocyte-lysosome fusion