Flavonoid compounds of tapak liman plant (Elephantopus scaber) as antihyperuricemia

Kartika Jurnal Ilmiah Farmasi Pub Date : 2022-01-31 DOI:10.20885/jif.specialissue2022.art4

N. Gunarti, Himyatul Hidayah

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Abstract

Abstract Background: Hyperuricemia is a condition where uric acid levels in the blood increase more than 6 mg/dL. Tapak liman (Elephantopus scaber) contains flavonoid compounds that are reported to inhibit the activity of the xanthine oxidase enzyme that causes hyperuricemia. Several Asteraceae tribes have activity as antihyperuricemia, one of which is the tapak liman plant (E. scaber) because of the compounds contained in the flavonoid group which has a working mechanism as an inhibitor of the xanthine oxidase enzyme. Objective: To determine the types of flavonoid compounds in tapak liman (E. scaber) plants that have antihyperuricemic activity. Method: This research is qualitative research using Literature Review Article (LRA) using Google Scholar, PubMed, ResearchGate, and Science direct databases with keywords related to the research topic, namely "Elephantopus scaber, antihyperuricemia, tapak liman, xanthine oxidase, flavonoids". Results: Compounds from the flavonoid group in tapak liman that have the potential as antihyperuricemia are luteolin compounds, luteolin-7-glucoside, quercetin, and rutin with the mechanism of inhibiting the activity of the xanthine oxidase enzyme. Conclusion: compounds from the flavonoid group in tapak liman that have the potential as antihyperuricemic compounds are luteolin, luteolin-7-glucoside, quercetin, and rutin. Keywords: Elephantopus scaber, antihyperuricemia, tapak liman, xanthine oxidase, flavonoids

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大象属植物黄酮类化合物抗高尿酸血症的研究

背景:高尿酸血症是血液中尿酸水平升高超过6 mg/dL的一种情况。Tapak liman(象皮)含有类黄酮化合物，据报道可以抑制引起高尿酸血症的黄嘌呤氧化酶的活性。一些菊科植物具有抗高尿酸血症的活性，其中一种是tapak liman植物(E. scaber)，因为它所含的黄酮类化合物具有黄嘌呤氧化酶抑制剂的作用机制。目的:确定具有抗高尿酸血症活性的黄酮类化合物的种类。方法:利用谷歌Scholar、PubMed、ResearchGate、Science direct等数据库，以与研究课题相关的关键词“象皮、抗高尿酸血症、tapak liman、黄嘌呤氧化酶、黄酮类化合物”，采用文献综述文章(LRA)进行定性研究。结果:番荔枝中具有抗高尿酸作用的黄酮类化合物为木犀草素类化合物、木犀草素-7-葡萄糖苷类化合物、槲皮素类化合物和芦丁类化合物，其作用机制是抑制黄嘌呤氧化酶的活性。结论:番荔枝中黄酮类化合物为木犀草素、木犀草素-7-葡萄糖苷、槲皮素和芦丁，具有抗高尿酸血症的潜力。关键词:象皮，抗高尿酸血症，塔帕克利曼，黄嘌呤氧化酶，黄酮

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Kartika Jurnal Ilmiah Farmasi

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16 weeks