Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats

Severyanova La, Plotnikov Dv
{"title":"Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats","authors":"Severyanova La, Plotnikov Dv","doi":"10.4172/2157-2526.1000160","DOIUrl":null,"url":null,"abstract":"We studied the effects of ACTH4-7 (the N-terminal fragment of the corresponding pituitary hormone molecule) on the pain-induced aggressive-defensive behavior in the foot-shock model in rats. The peptide was administered intraperitoneally in the saline at the doses 17, 50, 150 and 450 mcg/kg 12 min before the unavoidable painful stimulation of a pair of rats in an electrified camera. The analgesic and anti-aggressogenic effects of the peptide were found. These effects were significally enhanced after administration of the peptides synthesized by means of binding of the amino acids chain Pro-Gly-Pro to one or both ends of ACTH4-7 molecule. The data obtained increase the possibility of searching and using drugs to correct aggression.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"22 1","pages":"1-3"},"PeriodicalIF":0.0000,"publicationDate":"2018-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bioterrorism and Biodefense","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2157-2526.1000160","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

We studied the effects of ACTH4-7 (the N-terminal fragment of the corresponding pituitary hormone molecule) on the pain-induced aggressive-defensive behavior in the foot-shock model in rats. The peptide was administered intraperitoneally in the saline at the doses 17, 50, 150 and 450 mcg/kg 12 min before the unavoidable painful stimulation of a pair of rats in an electrified camera. The analgesic and anti-aggressogenic effects of the peptide were found. These effects were significally enhanced after administration of the peptides synthesized by means of binding of the amino acids chain Pro-Gly-Pro to one or both ends of ACTH4-7 molecule. The data obtained increase the possibility of searching and using drugs to correct aggression.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
甘脯氨酸类化合物对大鼠疼痛性攻击-防御行为中Acth-4-7作用的影响
我们研究了ACTH4-7(相应垂体激素分子n端片段)对足休克模型大鼠疼痛性攻击-防御行为的影响。在对一对大鼠进行不可避免的疼痛刺激前12分钟,以17、50、150和450 mcg/kg的剂量在生理盐水中腹腔注射该肽。发现该肽具有镇痛和抗侵袭作用。通过结合氨基酸链Pro-Gly-Pro与ACTH4-7分子的一端或两端合成的肽,这些作用在给药后显着增强。所获得的数据增加了寻找和使用药物来纠正攻击性的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats Features of Bioterrorism Information System Rift Valley Fever in Chronic Carrier and Liver Manifestations Changes in U.S. Biosecurity Following the 2001 Anthrax Attacks Global Biothreat and Cross-Border Resource Management: Some Findings
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1