{"title":"ONE-DIMENSIONAL BIOLOGICAL MODEL OF SYNOVIAL JOINTS REGENERATIVE REHABILITATION IN OSTEOARTHRITIS","authors":"V. Popov, Aleksandr M. Poliakov, V. Pakhaliuk","doi":"10.22190/fume220203014p","DOIUrl":null,"url":null,"abstract":"This work is devoted to the study of a one-dimensional phenomenological model of a focal defect regenerative rehabilitation in the articular cartilage. The model is based on six differential equations in partial derivatives of the “Diffusion-Reaction” type, which was previously used by a number of authors to study cellular processes in various tissues under cell therapy conditions. To take into account the influence of moderate mechanical stimulation of immature tissue, an indirect approach was used, as a result of which some model parameters that directly affect cell proliferation and differentiation were varied considering experimental data. The results of the model study show that moderate stimulation of immature tissue in the early stages of repair the focal articular cartilage defect under conditions of cell therapy leads to an intensification of regenerative processes in the tissue and promotes more rapid formation of the extracellular matrix.","PeriodicalId":51338,"journal":{"name":"Facta Universitatis-Series Mechanical Engineering","volume":null,"pages":null},"PeriodicalIF":10.1000,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Facta Universitatis-Series Mechanical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.22190/fume220203014p","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MECHANICAL","Score":null,"Total":0}
引用次数: 2
Abstract
This work is devoted to the study of a one-dimensional phenomenological model of a focal defect regenerative rehabilitation in the articular cartilage. The model is based on six differential equations in partial derivatives of the “Diffusion-Reaction” type, which was previously used by a number of authors to study cellular processes in various tissues under cell therapy conditions. To take into account the influence of moderate mechanical stimulation of immature tissue, an indirect approach was used, as a result of which some model parameters that directly affect cell proliferation and differentiation were varied considering experimental data. The results of the model study show that moderate stimulation of immature tissue in the early stages of repair the focal articular cartilage defect under conditions of cell therapy leads to an intensification of regenerative processes in the tissue and promotes more rapid formation of the extracellular matrix.
期刊介绍：
Facta Universitatis, Series: Mechanical Engineering (FU Mech Eng) is an open-access, peer-reviewed international journal published by the University of Niš in the Republic of Serbia. It publishes high-quality, refereed papers three times a year, encompassing original theoretical and/or practice-oriented research as well as extended versions of previously published conference papers. The journal's scope covers the entire spectrum of Mechanical Engineering. Papers undergo rigorous peer review to ensure originality, relevance, and readability, maintaining high publication standards while offering a timely, comprehensive, and balanced review process.
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