Effect of triple therapy of chemoradiotherapy, intracavitary brachytherapy and hyperthermia on advanced cervical cancer

Abstract

Objective To investigate the effects of triple therapy of chemoradiotherapy, intracavitary brachytherapy and hyperthermia in the treatment of advanced cervical cancer. Methods A total of 400 patients with advanced cervical cancer admitted to Shanxi Cancer Hospital from July 2011 to June 2016 were selected as the research subjects. They were divided into study group and control group according to the random number table method. Patients in the control group were treated by conventional chemoradiotherapy and intracavitary brachytherapy, and patients in the study group were treated by hyperthermia on the basis of treatment for control group. The curative effects and the changes of leptin and insulin like growth factor 2 (IGF2) in cervical cancer cells before and after treatment were compared between the two groups. After treatment, patients in the two groups were followed up for 3 years, and the tumor-free survival and death of the two groups were recorded. Results The short-term total effective rate of the study group was 74.00% (148/200), higher than the 53.00% (106/200) of the control group (P 0.05). After treatment, the levels of IGF2 and leptin in the study group were lower than those in the control group (P<0.05). During the 3-year follow-up period, the tumor-free survival rate (62.00%, 124/200) and case fatality rate (5.00%, 10/200) in the study group were significantly lower than the 30.50% (61/200) and 17.00%(34/200) in the control group(P<0.05). Conclusions Triple therapy of chemoradiotherapy, intracavitary brachytherapy and hyperthermia is effective in the treatment of advanced cervical cancer, which is beneficial to the short-term and long-term clinical effect. Key words: Chemoradiotherapy; Advanced cervical cancer; Intraluminal brachytherapy; Hyperthermia