Research progress of skeletal muscle dysfunction and related pulmonary rehabilitation in chronic obstructive pulmonary disease

Abstract

As one of the common extrapulmonary effects of chronic obstructive pulmonary disease, skeletal muscle dysfunction seriously affects patients′ exercise endurance, quality of life and prognosis.The mechanism may be that under the action of multifactorial etiology, some biological events occur in skeletal muscle, such as structural abnormality, oxidative stress, muscle protein metabolism disorder (increased proteolysis/decreased protein synthesis), autophagy, epigenetic regulation, cell apoptosis, endoplasmic reticulum stress, etc.At present, exercise training, neuromuscular electrical stimulation, nutritional support and other pulmonary rehabilitation interventions have been proved to be suitable for the prevention and treatment of skeletal muscle dysfunction. Key words: Pulmonary disease, chronic obstructive; Skeletal muscle dysfunction; Biological mechanisms; Pulmonary rehabilitation