The Impact of Propanol, N-Butanol and Pentanol on Aqueous Dispersions of Sonicated Liposomes. EPR Study

Agnieszka Bartnikowska, B. Pytel, D. Man
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Abstract

Abstract This paper presents the effect of selected alcohols on the fluidity of liposome membranes obtained in sonication of DPPC lecithin. Using the EPR technique, the duality of propanol, n-butanol and pentanol on the behaviour of the aqueous dispersion of liposomes was demonstrated. It was shown that after exceeding a certain concentration, these alcohols initiate dispersion foaming, leading to phase separation: liposome dispersion - lipid foam. The influence of the shape of the molecule and the length of hydrocarbon chains on the effectiveness of destabilisation of the structure of lipid membranes was indicated.
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丙醇、正丁醇和正丁醇对超声脂质体水分散的影响。电子顺磁共振研究
摘要本文研究了不同醇类对超声提取DPPC卵磷脂所得脂质体膜流动性的影响。利用EPR技术,证明了丙醇、正丁醇和戊醇的二元性对脂质体水分散行为的影响。结果表明,在超过一定浓度后,这些醇引发分散性泡沫,导致相分离:脂质体分散-脂质泡沫。指出了分子形状和烃链长度对脂质膜结构失稳效果的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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