Effect of menopause on lipid profile in relation to body mass index

Geetanjali Bade, Swati Shah, P. Nahar, S. Vaidya
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引用次数: 32

Abstract

Background: Menopause is a natural event in the ageing process and signifies the end of reproductive years with cessation of cyclic ovarian function as manifested by cyclic menstruation. Lipid profile is altered in menopause because of various reasons. Objectives: The study was aimed to compare the lipid profile in women with normal body mass index (BMI) = 18.9-24.9 and women with BMI = 25-29.9 in both pre- and post-menopausal group. Materials and Methods: Estimation of total cholesterol (TC) by CHOD-PAP Cholesterol Oxidase - Peroxidase + Aminophenazone + Phenol method, triglyceride (TG) by enzymatic calorimetric method, high density lipoprotein-cholesterol (HDL-C) phosphotungstic acid method, low density lipoprotein-cholesterol (LDL-C) by using Friedewald formula and very low density lipoprotein (VLDL) was done by using the formula -VLDL = TG/5 in 30 women selected in each group. Results: Our study revealed that serum levels of TC, TG and LDL-C were significantly higher in post-menopausal women in comparison to their pre-menopausal counterparts, irrespective of BMI ( P P Conclusions: We found that serum levels of TC, TG and LDL-C were significantly higher in post-menopausal women in comparison to their pre-menopausal counterparts, irrespective of BMI. Similarly, HDL-C levels were significantly lower in post-menopausal women as compared to pre-menopausal women of similar BMI. Since we found similar changes in women of different BMIs, the difference in hormonal status is the probable cause of altered lipid profile. Hence, all post-menopausal women irrespective of body weight and BMI should be strongly counseled to have proper physical exercise and dietary habits to avoid the possible cardiovascular complications.
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更年期对脂质分布与体重指数的影响
背景:绝经是衰老过程中的自然事件,标志着生殖年龄的结束,卵巢循环功能停止,表现为月经周期。由于各种原因,脂质谱在更年期发生改变。目的:本研究旨在比较绝经前和绝经后正常体重指数(BMI) = 18.9-24.9和BMI = 25-29.9的妇女的脂质谱。材料与方法:每组选取30例女性,采用CHOD-PAP法测定总胆固醇(TC),采用酶热法测定甘油三酯(TG),采用高密度脂蛋白-胆固醇(HDL-C)磷钨酸法测定低密度脂蛋白-胆固醇(LDL-C),采用公式-VLDL = TG/5测定极低密度脂蛋白(VLDL)。结果:我们的研究显示,绝经后妇女的血清TC、TG和LDL-C水平显著高于绝经前妇女,与BMI无关(P P)。结论:我们发现,与绝经前妇女相比,绝经后妇女的血清TC、TG和LDL-C水平显著高于绝经前妇女,与BMI无关。同样,与BMI相似的绝经前妇女相比,绝经后妇女的HDL-C水平明显较低。由于我们在不同bmi的女性中发现了类似的变化,激素状态的差异可能是脂质谱改变的原因。因此,所有绝经后妇女,不论体重和身体质量指数如何,都应强烈建议进行适当的体育锻炼和饮食习惯,以避免可能的心血管并发症。
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