Effect of Solanum melongena Linn. Leaves Extracts on Clonidine Induced Catalepsy and Milk Induced Leukocytosis and Eosinophilia in Mice

Abstract

Objective: To study the Effect of Solanum melongena Linn. leaves extracts on Clonidine induced catalepsy and milk induced Leukocytosis and Eosinophilia in mice. Methods: Methanolic and chloroform extracts of Solanum melongena Linn. leaves were prepared. Preliminary phytochemical screening of the prepared extracts was carried out. Effects of prepared extracts were studied on Clonidine induced catalepsy and milk induced leukocytosis and eosinophila in mice. Results: Maximum duration of catalepsy was observed at 90 min after the clonidine administration. There was significant inhibition (p˂0.05) of clonidine induced catalepsy in the animals pretreated with chlorpheniramine maleate, methanol and chloroform extract of S. melongena. Administration of milk (4mg/kg) subcutaneous route exhibited significant increase in leucocyte and eosinophil count after 24 hrs of administration. Chloroform extract at the dose of 500mg/kg body weight showed significant inhibition (p˂0.05) of milk induced leukocytosis and eosinophilia. Conclusions: These results suggest that Solanum melongena leaves extract may have the potential therapeutic value in the treatment of allergic diseases. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.