The cancer genome atlas - TCGA molecular classification: A changing paradigm in the management of endometrial cancers

Rahul A. Modi
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Abstract

Conventionally, endometrial cancers have been risk-stratified as per the clinco-pathological factors. The Cancer Genome Atlas project identified four distinct molecular subtypes within endometrial cancers which further lead to the clinical validation of molecular classification by various research groups. The molecular classification has influenced the risk stratification, thereby impacting adjuvant treatment decisions and prognostication. Molecular classification has paved the precision oncology in gynaecological cancers further strengthening the ongoing advances in targeted therapies and immunotherapy. This review elaborately presents the development of a new molecular classification of endometrial cancers; its evidence-based clinical utility with a brief overview of future perspectives.
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癌症基因组图谱- TCGA分子分类:子宫内膜癌管理的一个不断变化的范式
传统上,子宫内膜癌是根据临床病理因素进行风险分层的。癌症基因组图谱项目在子宫内膜癌中确定了四种不同的分子亚型,这进一步导致了不同研究小组对分子分类的临床验证。分子分类影响风险分层,从而影响辅助治疗决策和预后。分子分类为妇科肿瘤的精确肿瘤学奠定了基础,进一步加强了靶向治疗和免疫治疗的进展。这篇综述详细介绍了一种新的子宫内膜癌分子分类的发展;它的循证临床应用与未来前景的简要概述。
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