About the many faces of autism spectrum disorder: from psychoanalysis to biological markers. Could the methionine sulfoxide reductase enzymes play a role?

Abstract

Autism spectrum disorder is a dramatic condition for the affected children, their families and the entire society. Genetic and environmental factors are involved in its pathogenesis and oxidative stress appears to be the main trigger. Methionine sulfoxide reductase enzymes are physiologically involved in the contrast to oxidative stress and disorders in their expression/activity could result in several diseases. In the fight against autism spectrum disorder, this neglected biochemical feature should be taken into account.