A Robust Empirical Bayesian Method for Detecting Differentially Expressed Genes

Fugui Wang, Lin Hou, Jiangfeng Xu, M. Qian, Minghua Deng
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Abstract

With the increase in genome-wide experiments and sequenced genomes, the analysis of large data sets has become commonplace in biology. It is often the case that thousands of features in a genome-wide data set are tested against null hypotheses, where only a small number of features are expected to be significant. The empirical Bayesian method (EB) is one of the most powerful methods to address such an issue, which has attracted much attention in literature. Here we propose an altered EB method, which is more robust and gives a more reasonable statistical interpretation. Our method is applied on both simulated and real data, and it outperforms the EB method.
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一种鲁棒经验贝叶斯方法检测差异表达基因
随着全基因组实验和基因组测序的增加,对大数据集的分析在生物学中已经变得司空见惯。通常情况下,全基因组数据集中的数千个特征都是根据零假设进行测试的,其中只有少数特征预计是重要的。经验贝叶斯方法(empirical Bayesian method, EB)是解决这一问题最有力的方法之一,引起了文献的广泛关注。在这里,我们提出了一种改进的EB方法,它更稳健,并给出了更合理的统计解释。我们的方法在模拟和实际数据上都得到了应用,并且优于EB方法。
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