Abstract PO-095: Comparative analysis of breast tumor microbiome in Black non-Hispanic (BNH) and White non-Hispanic (WNH) women

J. Vishwanatha, S. Thyagarajan, M. Allen, Yan Zhang, N. Phillips, P. Chaudhary
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Abstract

Studies have demonstrated that environmental, host genetic, and socioeconomic factors influence the breast cancer prevalence landscape with a far-reaching influence on racial disparity to subtypes of breast cancer. To understand whether breast tissue harbors race-specific microbiota, we performed 16S rRNA gene-based sequencing of retrospective tumor and matched normal tissue adjacent to tumor (NAT) samples collected from Black non-Hispanic (BNH) and White non-Hispanic (WNH) women. Analysis of Triple Negative Breast cancer (TNBC) and Triple Positive Breast Cancer (TPBC) tissue for microbiota composition revealed significant differences in relative abundance of specific taxa at both phylum and genus levels between WNH and BNH women cohorts. Our main findings are that microbial diversity as measured by Shannon index was significantly lower in BNH TNBC tumor tissue as compared to matched NAT zone. In contrast, the WNH cohort had an inverse pattern for the Shannon index, when TNBC tumor tissue was compared to the matched NAT. Unweighted Principle Coordinate Analysis (PCoA) revealed a distinct clustering of tumor and NAT microbiota in both BNH and WNH cohorts. Citation Format: Jamboor K. Vishwanatha, Srikantha Thyagarajan, Michael Allen, Yan Zhang, Nicole Phillips, Pankaj Chaudhary. Comparative analysis of breast tumor microbiome in Black non-Hispanic (BNH) and White non-Hispanic (WNH) women [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-095.
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PO-095:非西班牙裔黑人(BNH)和非西班牙裔白人(WNH)女性乳腺肿瘤微生物组的比较分析
研究表明,环境、宿主遗传和社会经济因素影响乳腺癌的流行格局,并对乳腺癌亚型的种族差异产生深远影响。为了了解乳腺组织中是否存在种族特异性微生物群,我们对来自非西班牙裔黑人(BNH)和非西班牙裔白人(WNH)女性的回顾性肿瘤和匹配的正常肿瘤邻近组织(NAT)样本进行了16S rRNA基因测序。对三阴性乳腺癌(TNBC)和三阳性乳腺癌(TPBC)组织微生物群组成的分析显示,WNH和BNH女性队列在门和属水平上的特定分类群的相对丰度存在显著差异。我们的主要发现是,与匹配的NAT区相比,BNH TNBC肿瘤组织中Shannon指数测量的微生物多样性显著降低。相比之下,当将TNBC肿瘤组织与匹配的NAT进行比较时,WNH队列的Shannon指数呈现相反的模式。非加权原则坐标分析(PCoA)显示,BNH和WNH队列中肿瘤和NAT微生物群具有明显的聚类。引文格式:Jamboor K. Vishwanatha, Srikantha Thyagarajan, Michael Allen, Yan Zhang, Nicole Phillips, Pankaj Chaudhary。非西班牙裔黑人(BNH)与非西班牙裔白人(WNH)女性乳腺肿瘤微生物组比较分析[摘要]。AACR虚拟会议论文集:第十三届AACR种族/少数民族和医疗服务不足人群癌症健康差异科学会议;2020年10月2-4日。费城(PA): AACR;癌症流行病学生物标志物,2020;29(12增刊):摘要nr PO-095。
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Abstract PO-083: A qualitative examination of race, racism, residential segregation and cancer survivorship among Black and Hispanic women Abstract PO-095: Comparative analysis of breast tumor microbiome in Black non-Hispanic (BNH) and White non-Hispanic (WNH) women Abstract A119: Ethnic and sex differences in exposure to traffic-related air pollutants and lung cancer incidence: The Multiethnic Cohort Abstract A051: Race and gender differences in awareness of colorectal cancer screening tests among recently diagnosed colon cancer Abstract B004: Capacity development among patient navigators to enhance colorectal cancer control in American Indian-serving healthcare facilities in the U.S. Southwest and Southern Plains
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