Cardiovascular manifestations and echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 (MIS-C): A retrospective study

Jashvanth H J, S. Rudrappa, Pratibha Manjunath Patagar
{"title":"Cardiovascular manifestations and echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 (MIS-C): A retrospective study","authors":"Jashvanth H J, S. Rudrappa, Pratibha Manjunath Patagar","doi":"10.32677/ijch.v8i11.3130","DOIUrl":null,"url":null,"abstract":"Background: The multisystem inflammatory syndrome in children (MIS-C) has been described recently during COVID-19 pandemic. It is a delayed post-infectious response with a lag time of 4–6 weeks following the exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), involving multiple systems which is being increasingly reported worldwide. Aim: The study aims to investigate and report the cardiovascular manifestation and echocardiographic findings in pediatric patients diagnosed with MIS-C. Materials and Methods: The present study is a retrospective analysis of clinical data gathered from 40 admitted children diagnosed with MIS-C. The study was conducted for 1 year (from 1st June 2020 to 30th May 2021) at Cheluvamba Hospital, a tertiary care center attached to Mysore Medical College And Research Institute, Mysore, Karnataka. Results: Out of 40 children, 21 (52.5%) had manifestation of cardiovascular system in the form of shock, requiring ionotropic support and care at the Intensive Care Unit. Among them, 90% patients show elevated cardiac biomarker (Troponin T), 33.3% had two-dimensional echocardiographic (2D echo) findings in which 9.5% show coronary artery dilatation and 23.8% show left ventricular hypertrophy. Conclusion: MIS-C is a hyperinflammatory syndrome related to SARS-CoV-2 infection. Cardiac involvement is evidenced by perturbation of cardiac chamber size, function, coronary artery abnormalities, and elevated cardiac biomarker. Though, most of the patients responded to the initial treatment and recovered, there is scarcity of data regarding long-term cardiovascular complication.","PeriodicalId":22476,"journal":{"name":"The Indian journal of child health","volume":"15 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Indian journal of child health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32677/ijch.v8i11.3130","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: The multisystem inflammatory syndrome in children (MIS-C) has been described recently during COVID-19 pandemic. It is a delayed post-infectious response with a lag time of 4–6 weeks following the exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), involving multiple systems which is being increasingly reported worldwide. Aim: The study aims to investigate and report the cardiovascular manifestation and echocardiographic findings in pediatric patients diagnosed with MIS-C. Materials and Methods: The present study is a retrospective analysis of clinical data gathered from 40 admitted children diagnosed with MIS-C. The study was conducted for 1 year (from 1st June 2020 to 30th May 2021) at Cheluvamba Hospital, a tertiary care center attached to Mysore Medical College And Research Institute, Mysore, Karnataka. Results: Out of 40 children, 21 (52.5%) had manifestation of cardiovascular system in the form of shock, requiring ionotropic support and care at the Intensive Care Unit. Among them, 90% patients show elevated cardiac biomarker (Troponin T), 33.3% had two-dimensional echocardiographic (2D echo) findings in which 9.5% show coronary artery dilatation and 23.8% show left ventricular hypertrophy. Conclusion: MIS-C is a hyperinflammatory syndrome related to SARS-CoV-2 infection. Cardiac involvement is evidenced by perturbation of cardiac chamber size, function, coronary artery abnormalities, and elevated cardiac biomarker. Though, most of the patients responded to the initial treatment and recovered, there is scarcity of data regarding long-term cardiovascular complication.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
与COVID-19相关的儿童多系统炎症综合征(MIS-C)的心血管表现和超声心动图表现:一项回顾性研究
背景:最近在COVID-19大流行期间,出现了儿童多系统炎症综合征(MIS-C)。它是在接触严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)后出现的延迟感染后反应,滞后时间为4-6周,涉及多个系统,在世界范围内的报道越来越多。目的:本研究旨在探讨和报道小儿miss - c的心血管表现和超声心动图表现。材料和方法:本研究回顾性分析了40例确诊为MIS-C的住院儿童的临床资料。该研究在Cheluvamba医院进行了为期一年(从2020年6月1日至2021年5月30日),该医院是卡纳塔克邦迈索尔医学院和研究所附属的三级护理中心。结果:40例患儿中有21例(52.5%)出现心血管系统休克表现,需在重症监护室接受促电离性支持和护理。其中90%的患者表现为心脏生物标志物(肌钙蛋白T)升高,33.3%的患者表现为二维超声心动图(2D echo),其中9.5%表现为冠状动脉扩张,23.8%表现为左室肥厚。结论:misc是一种与SARS-CoV-2感染相关的高炎症综合征。心脏受累表现为心腔大小、功能、冠状动脉异常和心脏生物标志物升高。虽然大多数患者对初始治疗有反应并康复,但缺乏关于长期心血管并发症的数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Clinical and etiopathological profile of pancytopenia in children (1-18 years): A study from tertiary care center of Bundelkhand region, central India Urinary tract infection in pediatric patients – Recent updates Pediatric autism spectrum disorder: Role of yoga prana vidya system as complementary medicine in accelerating patient progress An observational study to evaluate weight gain of exclusively breastfed infants who feed only while sleeping Fibular hemimelia in a neonate
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1