The Hidden Face of Nitrogen Oxides Species: From Toxic Effects to Potential Cure?

Emerging Pollutants - Some Strategies for the Quality Preservation of Our Environment Pub Date : 2018-07-04 DOI:10.5772/INTECHOPEN.75822

Ségolène Depayras, T. Kondakova, H. Heipieper, M. Feuilloley, N. Orange, C. Duclairoir-Poc

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引用次数: 10

Abstract

Nitrogen oxide (NOx) species represent ones of the most threatening air pollutants due to their prevalence and harmful impact on the environment and human health. The term NOx gathers mainly nitric oxide (NO) and nitrogen dioxide (NO 2 ), mostly produced by anthropogenic activities such as transport and industries. Several cellular constituents were already described as NOx targets. These include membranes, proteins, respiratory chain enzymes, lipids, and DNA. Such damages lead to pathologies of lungs, cardiovascular system, and skin because these organs represent the first barrier toward the environment. On the other hand, NOx is also naturally synthetized by several organisms, playing a mediator role in essential cellular functions. However, few data are yet available on NOx activity toward microorganisms. Here, we review data concerning the double face of NOx, including their use in the medical field against pathogens’ infections that highlight the versatility of these compounds. HSP70, HSP90, and NOSIP, NOS-interacting protein; NOSTRIN, NOS traffic

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氮氧化物物种的隐藏面孔:从毒性效应到潜在的治疗?

氮氧化物(NOx)由于其普遍存在和对环境和人类健康的有害影响而成为最具威胁性的空气污染物之一。NOx一词主要是指一氧化氮(NO)和二氧化氮(NO 2)，主要是由交通和工业等人为活动产生的。几种细胞成分已经被描述为NOx目标。这些物质包括膜、蛋白质、呼吸链酶、脂质和DNA。这种损害会导致肺部、心血管系统和皮肤的病变，因为这些器官是与环境隔绝的第一道屏障。另一方面，氮氧化物也由几种生物自然合成，在细胞基本功能中起中介作用。然而，关于氮氧化物对微生物活性的数据很少。在这里，我们回顾了有关氮氧化物双面的数据，包括它们在医学领域对抗病原体感染的应用，突出了这些化合物的多功能性。HSP70、HSP90和NOSIP, nos相互作用蛋白;诺斯特恩，没有交通

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Emerging Pollutants - Some Strategies for the Quality Preservation of Our Environment

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