Physical stability and subjective efficacy study of liposome loaded with Clitoria ternatea (butterfly pea) flower extract and Eugenia caryophyllus (clove) oil

Abstract

Clitoria ternatea, commonly known as butterfly pea or blue pea, is an edible plant species belonging to the Fabaceae family. The plant has several therapeutic activities like a memory enhancer, antidepressant, antistress, sedative agent, anxiolytic and tranquilizing agent . The C. ternatea blue flower contains anthocyanins, which are mainly delphinidin-glucosides. The blue flowers of butterfly peas have good free radical scavenging activity and have potential as antioxidants. The flower is commonly used as a source of natural coloring agent for food and cosmetics and as a natural pH indicator in pharmaceutical industry. It has been reported that the butterfly pea flower fermentation solution can be added to cosmetic formula as a natural raw material of skin care products to improve moisture retention and had whitening effects. The application of crushed fresh butterfly pea flower (also known as Aunchan) directly on the eyebrows and scalp for the benefits of coloring and promoting hair growth is traditionally and commonly found in Thailand. The ability to promote hair growth may be related with its inhibition of the 5α-reductase enzyme activity. Clove (Eugenia caryophyllus) is an important medicinal plant that has been employed for centuries as food preservative and pain reliever. It is also claimed to be the rich source of phenolic antioxidants. Eugenol and eugenyl acetate, which are poorly water soluble