{"title":"8-Oxo-2'-Deoxyguanosine - Biomarker, Signal Molecule, Potential Pharmaceutical Agent","authors":"N. Marmiy, D. Esipov","doi":"10.15688/JVOLSU11.2018.1.9","DOIUrl":null,"url":null,"abstract":"The study is devoted to 8-oxo-2'-deoxyguanosine (8-oxo-dG), which is used as a biomarker of oxidative damage to DNA and its associated diseases. The study is based on the hypothesis put forward by the authors about the ability of 8-oxo-dG, which is the main product of DNA oxidation, to act as a signal molecule that activates cell resistance to nonspecific stress and DNA repair. In addition to studying the molecular mechanisms of the action of 8-oxo-dG, the authors have carried out an investigation of the effects that they caused on the organism level.","PeriodicalId":30925,"journal":{"name":"Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki","volume":"98 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15688/JVOLSU11.2018.1.9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The study is devoted to 8-oxo-2'-deoxyguanosine (8-oxo-dG), which is used as a biomarker of oxidative damage to DNA and its associated diseases. The study is based on the hypothesis put forward by the authors about the ability of 8-oxo-dG, which is the main product of DNA oxidation, to act as a signal molecule that activates cell resistance to nonspecific stress and DNA repair. In addition to studying the molecular mechanisms of the action of 8-oxo-dG, the authors have carried out an investigation of the effects that they caused on the organism level.
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