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Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki最新文献

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Development of Multifunctional Laboratory in Chip for Molecular Diagnostics of Infections 感染分子诊断芯片多功能实验室的研制
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.1.12
N. G. Sandetskaya, Dirk Kulmaher, Christian Cilh
In the present research the authors carry out a comparative analysis of the effectiveness of different methods for isolating bacteria from samples using a MinoLyzer device, a MinoCard chip cartridge and polymerase chain reaction (PCR) method.
在本研究中,作者对MinoLyzer装置、MinoCard芯片盒和聚合酶链反应(PCR)法从样品中分离细菌的不同方法的有效性进行了比较分析。
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引用次数: 0
Comparison of the Central and Peripheral Components of Action in Comprehensive Analgesic Activity of New Kappa-Agonist 新型kappa激动剂中枢和外周镇痛作用的比较
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.1.5
V. Batrakov, D. D. Shamshina, A. Ivanov
Elimination of the pain syndrome is still an urgent task in various fields of medicine. Therefore, the problem of finding new effective and safe analgesics remains today one of the most important. The research is aimed at comparing the central and peripheral analgesic activity of chemical mixture KOR 205 in an experiment in rats. Based on the results of the experimental work, indicators of the maximum possible effect (MVE%) have been determined. The KOR 205 compound has a more pronounced central analgesic effect, compared with peripheral analgesic activity.
消除疼痛综合征仍然是医学各个领域的紧迫任务。因此,寻找新的有效和安全的镇痛药仍然是当今最重要的问题之一。本研究旨在比较化学混合物KOR 205对大鼠中枢和外周镇痛活性的影响。根据实验结果,确定了最大可能效果的指标(MVE%)。与外周镇痛活性相比,KOR 205化合物具有更明显的中枢镇痛作用。
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引用次数: 5
About Systems of Telecontrol – Biotechnology Control 关于遥控系统-生物技术控制
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.1.13
M. Postnova, A. Sklyar
Currently, powerful modern poultry farms require built-in logistics with an optimized structure of control and management. Such a system requires formalization and ranking, responding to the tasks of specific divisions of enterprises and poultry farms in general. The analysis of the robots on the Russko-Vysotskaya site shows positive results when the Big Dutchman company introduced the BigFarmNet Manager and AMAKS systems for 11 years of operation of this complex allowing to regulate and control the production processes of egg processing, feeding, drinking, to manage the microclimate of poultry houses in real time from the central office or from a portable personal computer using the Internet.
目前,强大的现代家禽养殖场需要内置物流和优化的控制和管理结构。这样的制度需要正规化和排序,以响应企业和家禽养殖场的特定部门的任务。对Russko-Vysotskaya基地机器人的分析显示出积极的结果,当大荷兰人公司引进BigFarmNet Manager和AMAKS系统,该综合体运行了11年,允许调节和控制鸡蛋加工,喂养,饮用的生产过程,通过中央办公室或使用互联网的便携式个人电脑实时管理家禽舍的小气候。
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引用次数: 0
Ways to Reduce Energy Costs in Poultry Farms 降低家禽养殖场能源成本的方法
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.2.13
A. Sklyar, M. Postnova
Currently, the modern poultry farms are located in regions with different climatic conditions. Thus, the component of the electric power being the base for combined heating and ventilating systems, lighting, and local heating of poultry farms, is great in power engineering on the territory of the Russian Federation. The analysis of energy costs of poultry farms showed that of the estimated options for reducing the cost of electricity for poultry farms, one of the most effective can be an alternative source such as the generation of own electricity. Naturally, for biological production with a continuous technological cycle (poultry farming, for example), seems to be replace about 45-55 % of the needs of the factory and serve as a reserve for the rest, but not cover all 100 % of needs.
目前,现代家禽养殖场分布在气候条件不同的地区。因此,电力的组成部分是联合供暖和通风系统、照明和家禽养殖场的局部供暖的基础,在俄罗斯联邦领土上的电力工程中占有重要地位。对家禽养殖场能源成本的分析表明,在减少家禽养殖场电力成本的估计选择中,最有效的选择之一可能是替代来源,例如自己发电。当然,对于具有连续技术周期的生物生产(例如家禽养殖),似乎可以替代工厂约45- 55%的需求,并作为其余部分的储备,但不能满足所有100%的需求。
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引用次数: 0
The Synopsis of the Genus Phleum L. (Poaceae) in Flora of The Kyrgyz Republic 文章题目吉尔吉斯共和国植物区系中草属植物概述
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.2.2
Adilet Usupbaev
On the base of investigation of material kept in Herbarium of flora laboratory (Institute for Biology and Pedology, National Aсademy of Sciences (FRU), a synopsis of the genus Phleum L. (Poaceae) in flora of Kyrgyz Republic with a key for identification of species and short citats is presented. Six species are recognized in Kyrgyz Republic (Phleum phleoides H. Karst., Phleum himalaicum Mez, Phleum paniculatum Huds., Phleum pratense L., Phleum roshevitzii Pavlov, Phleum alpinum L.). Phleumroshevitzii Pavlov newly reported for Kyrgyz Republic (Issyk-Kul Lake depression, Northern Kyrgyzstan). Maps of distribution for species growing in Kyrgyz Republic (Laskov GA., Sultanova BA., 2011) and list of studied specimens are provided. NK - Northern Kyrgyzstan (Chu Valley with adjacent northern macro-slope of Alexander Mountain Range, and the basin of Chon-Kemin River); IK - Issyk-Kul Lake depression (including northern macro-slope of TerskeiAla-Too Mountain Range, southern slope of KungeiAla-Too Mountain Range, basins of Tyup, Jergalan, and Karkyra rivers); CT - Central Tien Shan (basin of the Sary-Dzhaz River); WT - esternTien Shan (Talas and Chatkal valleys together with slopes of adjacent mountain ranges, and Ketmen-Tyube Valley); F - Cis-Ferghanian Kyrgyzstan (edges of the Fergana Valley, with adjacent macro-slopes of Chatkal Mountain Range, Fergana Mountain Range, Turkestan Mountain range, and Alai Mountain System); IT - Inner Tien Shan (the area bounded in the north by Kyrgyz Mt. Ridge, in the southwest by Fergana Mountain Range, and in the south-east by Kokshaal-Too Mountain System); А - Alai Valley (including southern macro-slope of Alai Mts. and northern macro-slope of Trans-Alai Mt. Range); EK - Entire territory of Kyrgyzstan (i. e. species is registered in all of abovementioned regions).Kyrgyz Republic is located in the centre of Eurasia. The distance to an Indian Ocean is about 3 000 km. The total square is about 198,500 km2. Altitudes are from 410 to 7 439 m above sea level. Over 90 % of the territory is elevated above 1 500 m. About 40 % of nearly uninhabitable: glaciers, permanent snow, rocks, scree, alpinedesert, etc. Ca. 7 % of territory is occupied by the cultural landscape: fields, settlements, roads, and industry (Atlas…1987). Only the main literature sources are cited for species: “Flora URSS” (Ovczinnikov, 1934), “Flora of Kirghiz SSR”(Nikitina, 1950), “Conspectus florae AsiaeMediae” (Gamajunova, 1968), and also the monograph of Tzvelev NN. “Grasses of URSS” (Tzvelev, 1976). The article contains 1 Figures, 1 key for identification of species, and 11 References.
在对国家科学院植物实验室(生物与土壤研究所)植物标本室保存的资料进行调查的基础上,对吉尔吉斯共和国植物区系中Phleum L. (Poaceae)属植物进行了概述,并给出了物种和短柠檬酸鉴别的关键字。在吉尔吉斯共和国已发现6种(Phleum phleoides H. Karst)。,喜马拉雅菌群,圆锥菌群。,蒲公英,蒲公英,蒲公英,蒲公英。在吉尔吉斯共和国(吉尔吉斯斯坦北部伊塞克-库尔湖洼地)新报道的Phleumroshevitzii Pavlov。标题吉尔吉斯共和国种分布图(Laskov GA)。Sultanova文学学士。(2011),并提供了研究标本清单。NK -吉尔吉斯斯坦北部(与亚历山大山脉北部大斜坡相邻的楚河谷和春克敏河流域);IK - Issyk-Kul湖坳陷(包括TerskeiAla-Too山脉北部大斜坡、KungeiAla-Too山脉南部斜坡、Tyup河、Jergalan河和Karkyra河流域);CT -天山中部(sari - dzhaz河流域);WT -天山西部(Talas和Chatkal山谷连同邻近山脉的斜坡,以及ketman - tyube山谷);F - cis - ferghian吉尔吉斯斯坦(费尔干纳山谷边缘,毗邻Chatkal山脉、费尔干纳山脉、土耳其斯坦山脉和阿莱山系的大斜坡);IT -内天山(北部是吉尔吉斯山脉,西南是费尔干纳山脉,东南部是Kokshaal-Too山系);А -阿莱山谷(包括阿莱山脉南部大坡和跨阿莱山脉北部大坡);EK -吉尔吉斯斯坦全境(即在上述所有地区登记的物种)。吉尔吉斯共和国位于欧亚大陆的中心。到印度洋的距离约为3000公里。总面积约为19.85万平方公里。海拔高度从410米到7 439米。超过90%的地区海拔在1500米以上。大约40%的地区几乎不适合居住:冰川、永久积雪、岩石、碎石、高山沙漠等。约7%的领土被文化景观所占据:田野、定居点、道路和工业(Atlas…1987)。物种只引用了主要的文献来源:“Flora URSS”(Ovczinnikov, 1934),“Flora of kirkiz SSR”(Nikitina, 1950),“Conspectus florae AsiaeMediae”(Gamajunova, 1968),以及Tzvelev NN的专著。“URSS的草”(Tzvelev, 1976)。全文包含1张图,1个物种识别关键字,11篇参考文献。
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引用次数: 0
Methodology of Validation of In Silico 3D-Models of Pharmacologically Relevant Proteins-Targets 药理学相关蛋白靶点的计算机三维模型验证方法
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.1.16
L. Yanalieva, P. Vasilyev, A. Kochetkov
The article studies the development of methodology and results of validation of in silico 3D models of pharmacologically relevant target proteins on the example of protein kinase C theta. Using the IUPHAR / BPS database, information has been found about 5 reference inhibitors PRKCQ, recognized by the world scientific community. According to the received data, 3 most valid PRKCQ models (PDB-codes: 5F9E, 2JED, 4RA5) have been selected, which can later be used for docking of new inhibitors.
本文以蛋白激酶C θ为例,研究了药理学相关靶蛋白的计算机三维模型的方法学发展和验证结果。利用IUPHAR / BPS数据库,发现了5种被世界科学界认可的参考抑制剂PRKCQ。根据接收到的数据,选择了3个最有效的PRKCQ模型(pdb -code: 5F9E, 2JED, 4RA5),可用于对接新的抑制剂。
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引用次数: 0
The Non-Invasive System to Control Morphogenesis of Planaria as an Alternative Approach to Bioassessment 非侵入性系统控制涡虫形态发生作为生物评价的替代方法
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.1.3
Ulyana Vorobyeva, K. Novikov, O. Burlakova, V. Emelyanenko, K. Tiras
The published study tests our own chemical luminescence Planaria accompanying regeneration processes in combination with methods of in vivo fixation of their structure using non-invasive computer morphometry. As a result, we propose a new system of online remote control of morphogenesis in Planaria regeneration. This system is promising for primary screening of drugs – proliferation regulators.
发表的研究测试了我们自己的化学发光涡虫伴随再生过程,结合使用非侵入性计算机形态测量法在体内固定其结构的方法。因此,我们提出了一种新的涡虫再生形态发生在线远程控制系统。该系统有望用于药物增殖调节因子的初步筛选。
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引用次数: 1
8-Oxo-2'-Deoxyguanosine - Biomarker, Signal Molecule, Potential Pharmaceutical Agent 8-氧-2'-脱氧鸟苷-生物标志物,信号分子,潜在药物制剂
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.1.9
N. Marmiy, D. Esipov
The study is devoted to 8-oxo-2'-deoxyguanosine (8-oxo-dG), which is used as a biomarker of oxidative damage to DNA and its associated diseases. The study is based on the hypothesis put forward by the authors about the ability of 8-oxo-dG, which is the main product of DNA oxidation, to act as a signal molecule that activates cell resistance to nonspecific stress and DNA repair. In addition to studying the molecular mechanisms of the action of 8-oxo-dG, the authors have carried out an investigation of the effects that they caused on the organism level.
该研究致力于8-oxo-2'-脱氧鸟苷(8-oxo-dG),它被用作DNA氧化损伤及其相关疾病的生物标志物。该研究基于作者提出的8-oxo-dG (DNA氧化的主要产物)作为激活细胞抵抗非特异性应激和DNA修复的信号分子的能力的假设。除了研究8-oxo-dG作用的分子机制外,作者还对其在生物水平上造成的影响进行了调查。
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引用次数: 1
Algorithms of Three-Dimensional Reconstructionfor Building a Model of Spatial Distributionof Tissue Properties (on the Exampleof Articular Cartilage) 建立组织特性空间分布模型的三维重建算法(以关节软骨为例)
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.1.4
M. Grunina, V. Novochadov
The paper demonstrates relationship between morphological characteristics of articular cartilage and its functional properties in osteoarthritis. An automated analysis of the sections of the rat articular cartilage has revealed these mutual dependences. An algorithm for assessing the functional properties of cartilage by certain characteristics of its tissue in a natural full-color reconstruction is proposed.
本文论述了骨关节炎患者关节软骨形态特征与其功能特性之间的关系。对大鼠关节软骨切片的自动分析揭示了这些相互依赖性。提出了一种利用软骨组织的某些特征在自然全色重建中评估软骨功能特性的算法。
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引用次数: 0
Evaluation of the Influence of Preliminary Alcoholation on Activity of Microsomal Rat Liver Factions In Vitro 初步醇化对体外大鼠微粒体肝组织活性影响的评价
Pub Date : 2018-08-01 DOI: 10.15688/JVOLSU11.2018.1.11
N. Osadchenko, L. Knyshova, A. M. Dotsenko, A. Tarasov, A. Yakovlev
The present research is devoted to the study of the relationship between the structure of the original synthetic monophenolic antioxidants and their ability to influence the activity of autophagy in tumor cells.
本研究致力于研究原始合成的单酚类抗氧化剂的结构及其影响肿瘤细胞自噬活性的能力之间的关系。
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引用次数: 0
期刊
Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki
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