Evaluation of wound healing potential of Pterocarpus marsupium heart wood extract in normal and diabetic rats

Abstract

Aim: The aim of the present study is to evaluate and compare the cutaneous wound healing potential of Pterocarpus marsupium in normal and diabetic rats and make inference for the cutaneous wound healing potential by possible mode of action P. marsupium extract. Materials and Methods: The effect of heart wood extract of P. marsupium on wound healing has been studied in diabetic and normal animals. The effect has also been compared with standard (mupirocin ointment) application. In the absence of specific animal model for cutaneous diabetic wound healing, we have used common model of wound healing (excision wound model) in animals having diabetes (by administration of alloxan monohydrate 120 mg/kg i.p.). Statistics Analysis: Data were analyzed by using one-way ANOVA, followed by Tukey's post hoc tests, using the Graph Pad Software (5.0 demo version), and P value Results and Conclusion : Rats treated with 200 mg/kg/day of P. marsupium heart wood extract had high rate of wound contraction, significantly decreased epithelization period, and significant increase in dry weight, wet weight, and hydroxyproline content of the granulation tissue when compared with the diabetic control and normal control groups. Wound contraction together with increased tensile strength and hydroxyproline content support the use of P. marsupium heart wood extract in the management of wound healing in normal and diabetic rats.