Preparation And Evaluation Of Directly Compressible Tablets Of Ketoprofen Crystals

Abstract

Purpose: The aim of present investigation was to prepare the directly compressible tablets of Ketoprofen loaded crystals and the prepared tablets were evaluated for the improvement in drug release of Ketoprofen as compared to the pure drug. Methods: Ketoprofen crystals were prepared by solvent evaporation, a conventional method, with an excipient, saccharin sodium dihydrate at room temperature. Control batch of Ketoprofen was prepared by excluding the excipient in the preparation. The prepared crystals were converted to directly compressible tablet dosage form. Results: The crystal formation of Ketoprofen lead to improve the compressibility, mechanical properties, and tensile strength of the drug which enable to prepare directly compressible tablet dosage form. The In-vitro study demonstrated 2.71 fold increase in the drug release rate from tablets of Ketoprofen crystals compared to the pure drug after one hour. The characterization was done by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) study of Ketoprofen treated crystals illustrated the improvement in physicochemical, manufacturability, and pharmacotechnical parameters of Ketoprofen. Conclusions: The crystal engineering approach can be used to improve the physicomechanical and pharmacotechnical parameters of BCS Class-II drugs which enable to prepare directly compressible tablet dosage form. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Vaghela, P.D.; Tank, H.M. Preparation and evaluation of directly compressible tablets of ketoprofen crystals. Indo Global J. Pharm. Sci., 2020; 10(3): 21-34. DOI: http://doi.org/10.35652/IGJPS.2020.10303 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(3): 21-34 22 Dissolution Study 1. In-Vitro drug release study of directly compressible tablets of pure drug, its control batch, and Ketoprofen