Prooxidant-Antioxidant Balance of The Brain of Rats with Cerebral Ischemia with The Introduction Of L-Name, L-Arginine, And Omega-3 Polyunsaturated Fatty Acids

Lizaveta I. Bon
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Abstract

The search for new approaches to the treatment of acute ischemic stroke is one of the urgent problems of experimental and clinical neurology. This is due to the fact that cerebrovascular diseases of ischemic origin tend to grow, rejuvenate, are associated with a severe clinical course, high rates of disability and mortality. One of the promising neuroprotective amino acids is L-arginine. Most of the effects caused by this amino acid are associated with its ability to increase the formation of NO, acting as a source for its formation. An important role of ω-3 polyunsaturated fatty acids (Omega-3 PUFAs) is to ensure the functioning of cell membranes, transmembrane ion channels and the regulation of physiological processes through the synthesis of lipid mediators, which, lining up in the phospholipid layer of cell membranes, affect their fluidity. Cerebral ischemia is characterized by the activation of prooxidant mechanisms, as well as the inhibition of energy metabolism in the brain tissue. The introduction of the drug «Omega-3 PUFA» has a corrective effect on the indicators of oxidative stress in SCI. The use of «Omega-3 PUFA» in animals of the group with cerebral ischemia and the introduction of a non-selective NOS inhibitor – L-NAME did not have a positive effect.
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引入L-Name、l -精氨酸和Omega-3多不饱和脂肪酸对脑缺血大鼠大脑促氧化-抗氧化平衡的影响
寻找治疗急性缺血性脑卒中的新方法是实验和临床神经病学亟待解决的问题之一。这是因为缺血性脑血管疾病往往会生长、恢复活力,并伴有严重的临床病程、高致残率和死亡率。l -精氨酸是一种很有前途的神经保护氨基酸。这种氨基酸引起的大多数影响与它增加一氧化氮形成的能力有关,它是一氧化氮形成的来源。ω-3多不饱和脂肪酸(ω-3 PUFAs)的重要作用是通过合成脂质介质来保证细胞膜的功能、跨膜离子通道和生理过程的调节,这些介质排列在细胞膜的磷脂层中,影响细胞膜的流动性。脑缺血的特点是促氧化机制的激活,以及脑组织能量代谢的抑制。药物«Omega-3 PUFA»的引入对脊髓损伤的氧化应激指标有矫正作用。在脑缺血组的动物中使用“Omega-3 PUFA”和引入非选择性NOS抑制剂- L-NAME没有产生积极作用。
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