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Exploratory Model of Collaboration Networks in the COVID-19 Era 新冠肺炎时代协同网络的探索性模型
Pub Date : 2023-03-09 DOI: 10.58489/2836-8851/009
C. García-Lirios
knowledge networks and organizational collaboration reflect a culture of success, transformational leadership and a climate of relationships around which relationships of trust, support, innovation and goals are generated. These are bi-directional and horizontal organizations with equity and solidarity. The objective of the present study is to establish the correlations between the factors, a non-experimental, transversal and exploratory study was carried out with a selection of 300 administrative staff, students and teachers from a public university in central Mexico. to structural model. The results show that there is a dependence relationship between goal climate and collaboration. Based on these findings, research lines related to trust as a determinant of knowledge networks and organizational collaboration are noted.
知识网络和组织协作反映了一种成功文化、变革型领导和一种关系氛围,在这种氛围中,信任、支持、创新和目标的关系得以产生。这些是双向和横向的组织,具有公平和团结。本研究的目的是确定这些因素之间的相关性,对墨西哥中部一所公立大学的300名行政人员、学生和教师进行了一项非实验性、横向和探索性研究。到结构模型。结果表明,目标气候与协作之间存在依赖关系。在此基础上,本文指出了信任作为知识网络和组织协作的决定因素的研究路线。
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引用次数: 0
Prooxidant-Antioxidant Balance of The Brain of Rats with Cerebral Ischemia with The Introduction Of L-Name, L-Arginine, And Omega-3 Polyunsaturated Fatty Acids 引入L-Name、l -精氨酸和Omega-3多不饱和脂肪酸对脑缺血大鼠大脑促氧化-抗氧化平衡的影响
Pub Date : 2023-03-09 DOI: 10.58489/2836-8851/008
Lizaveta I. Bon
The search for new approaches to the treatment of acute ischemic stroke is one of the urgent problems of experimental and clinical neurology. This is due to the fact that cerebrovascular diseases of ischemic origin tend to grow, rejuvenate, are associated with a severe clinical course, high rates of disability and mortality. One of the promising neuroprotective amino acids is L-arginine. Most of the effects caused by this amino acid are associated with its ability to increase the formation of NO, acting as a source for its formation. An important role of ω-3 polyunsaturated fatty acids (Omega-3 PUFAs) is to ensure the functioning of cell membranes, transmembrane ion channels and the regulation of physiological processes through the synthesis of lipid mediators, which, lining up in the phospholipid layer of cell membranes, affect their fluidity. Cerebral ischemia is characterized by the activation of prooxidant mechanisms, as well as the inhibition of energy metabolism in the brain tissue. The introduction of the drug «Omega-3 PUFA» has a corrective effect on the indicators of oxidative stress in SCI. The use of «Omega-3 PUFA» in animals of the group with cerebral ischemia and the introduction of a non-selective NOS inhibitor – L-NAME did not have a positive effect.
寻找治疗急性缺血性脑卒中的新方法是实验和临床神经病学亟待解决的问题之一。这是因为缺血性脑血管疾病往往会生长、恢复活力,并伴有严重的临床病程、高致残率和死亡率。l -精氨酸是一种很有前途的神经保护氨基酸。这种氨基酸引起的大多数影响与它增加一氧化氮形成的能力有关,它是一氧化氮形成的来源。ω-3多不饱和脂肪酸(ω-3 PUFAs)的重要作用是通过合成脂质介质来保证细胞膜的功能、跨膜离子通道和生理过程的调节,这些介质排列在细胞膜的磷脂层中,影响细胞膜的流动性。脑缺血的特点是促氧化机制的激活,以及脑组织能量代谢的抑制。药物«Omega-3 PUFA»的引入对脊髓损伤的氧化应激指标有矫正作用。在脑缺血组的动物中使用“Omega-3 PUFA”和引入非选择性NOS抑制剂- L-NAME没有产生积极作用。
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引用次数: 0
The second case of Bardet-Biedl syndrome from Iraq: An educational article and expert opinion 伊拉克第二例baret - biedl综合征:一篇教育文章和专家意见
Pub Date : 2023-03-09 DOI: 10.58489/2836-8851/010
Aamir Jalal Al-Mosawi
Background: Bardet-Biedl syndrome and Laurence-Moon syndrome are rare autosomal recessive disorders with a similar phenotype. They are characterized by the gradual development of phenotype which includes cone-rod retinal dystrophy, obesity, and hypogonadism in males. Other associated abnormalities include learning disability and renal abnormalities. The two conditions are differentiated clinically by the presence of spasticity and the absence of polydactyly in Laurence-Moon syndrome. In 2002, we reported the first patient with Bardet-Biedl syndrome. The boy had polydactyly, obesity, retinal degeneration, and was hospitalized at the University Hospital in Al-Kadhimiyia because of the development of chronic renal failure. Patients and methods: The case of a 9-year-old obese Kurdish girl who had polydactyly of the hands and feet associated with reduced visual acuity is described. Results: A 9-year-old obese Kurdish girl had polydactyly of the hand and feet associated with reduced visual acuity that was attributed to myopia which was partially corrected with eye glasses. The parents were unrelated, and her younger 5-year sister had polydactyly of the feet only. No other family member known to have polydactyly. Both sisters had their extra-digits removed surgically. The girl was studying at fourth grade primary school and the parents reported no learning disability. Fundoscopy showed normal optic disc and periphery of the retina. The presence of retinitis pigmentosa was excluded. However, the foveal reflex was reported to be abnormal by the oophthalmologist. Electroretinography showed evidence of cone-rod dystrophy. Conclusion: The second case of Bardet-Biedl syndrome from Iraq is reported. The current evidence-based expert opinion suggests the use of long tem supplementation of citicoline, co-enzyme Q10 and lutein with hope of retarding the progression to blindness.
背景:Bardet-Biedl综合征和Laurence-Moon综合征是罕见的常染色体隐性遗传病,具有相似的表型。他们的特点是逐渐发展的表型,包括锥杆视网膜营养不良,肥胖,和性腺功能减退的男性。其他相关异常包括学习障碍和肾脏异常。在临床上,这两种情况的区别在于劳伦斯-莫恩综合征中存在痉挛和缺乏多指畸形。2002年,我们报道了第一例Bardet-Biedl综合征患者。该男孩患有多指畸形、肥胖、视网膜变性,并因发展为慢性肾衰竭而在Al-Kadhimiyia大学医院住院。患者和方法:一个9岁的肥胖库尔德女孩谁有多指畸形的手和脚与视力下降的情况下描述。结果:一名9岁的肥胖库尔德女孩患有手和脚的多指畸形,并伴有视力下降,这是由于近视引起的,部分用眼镜矫正。父母没有血缘关系,她5岁的妹妹只有足部多指畸形。没有其他家族成员有多指畸形。两姐妹都通过手术切除了多余的手指。这名女孩正在小学四年级学习,她的父母报告说她没有学习障碍。眼底镜检查显示视盘和视网膜周围正常。排除色素性视网膜炎。然而,眼科医生报告中央凹反射异常。视网膜电图显示锥杆营养不良。结论:报告了伊拉克第2例Bardet-Biedl综合征。目前以证据为基础的专家意见建议长期补充胞胆碱、辅酶Q10和叶黄素,以期延缓失明的进展。
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引用次数: 0
The Unified Theory of Medicine 医学统一理论
Pub Date : 2022-12-27 DOI: 10.58489/2836-8851/006
Lewis S. Coleman
There is only one health, but diseases are many. Likewise, there appears to be one fundamental force that heals, although the myriad schools of medicine all have their favorite ways of cajoling it into action.”—Robert O. Becker
健康只有一种,疾病却有许多种。同样,似乎有一种基本的力量可以治愈,尽管无数的医学流派都有他们最喜欢的方法来诱使它发挥作用。——罗伯特o贝克尔
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引用次数: 0
Perspectives and trends in research ethics: A necessity 研究伦理的观点和趋势:一种必要性
Pub Date : 2022-12-27 DOI: 10.58489/2836-8851/007
N. Johnkennedy
Research ethics involves application of fundamental ethical concepts to research activities, such as the planning and carrying out of research, respect for society and other people, the use of resources and research outputs, scientific misconduct and the regulation of research. It is a crucial component of research that is affected by factors like public trust in scientists, data protection, anonymity, and confidentiality, as well as the capacity to establish and maintain relationships of trust with respondents. It encompasses not only the rules spelled out in a code of ethics, but also the researcher's philosophical and value viewpoint. The research ethics and its principle are x-rayed.
研究伦理涉及将基本伦理概念应用于研究活动,例如研究的规划和开展、对社会和他人的尊重、资源和研究成果的使用、科学不端行为和研究监管。它是研究的一个重要组成部分,受公众对科学家的信任、数据保护、匿名和保密以及与受访者建立和维持信任关系的能力等因素的影响。它不仅包括道德规范中阐明的规则,还包括研究人员的哲学和价值观。研究伦理及其原则是透视的。
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引用次数: 0
Analysis Of the Psychological State of People During the Covid - 19 Pandemic 新冠肺炎疫情期间民众心理状态分析
Pub Date : 2022-12-21 DOI: 10.58489/2836-8851/001
K. M. Chandran
The COVID-19 pandemic could have affected people not only physically, but also psychologically. It is in this background that this study was undertaken by WEDO (NGO), Kozhikode, Kerala, India. Data was collected on-line using a questionnaire containing 15 psychological traits and their level of experience, and the characteristics of respondents such as age, sex, education etc. from a sample of 300 respondents from India using the snow ball sampling technique. The total score of the traits was worked out as the psychological state score. The data was analyzed as proportion / score and through statistical tests. The COVID-19 pandemic has influenced the psychology of the respondents negatively. The influence of existing tension of people in creating more tension during the pandemic period is evident from the study. Random Forest technique results show that Enthusiasm, Satisfaction, Loving nature and Peacefulness are the main psychological traits, which influence the personality state score. The characteristics of respondents such as age, education, pre COVID tension and pre COVID tension affecting the tension during the pandemic period are found to influence the personality score statistically through Chi-square test. Odds ratio test shows that respondents with PG qualification have about 4.62 times more chance of maintaining a better psychological state during the pandemic period than less educated people. Males have 1.16 times more chance of maintaining a better psychological state than females. The study has revealed the negative effect of the COVID-19 pandemic on the psychological state of people, with majority attributing this to the pandemic itself.
COVID-19大流行不仅会影响人们的身体,还会影响人们的心理。正是在这种背景下,印度喀拉拉邦Kozhikode的WEDO(非政府组织)进行了这项研究。数据是通过一份包含15种心理特征及其经验水平的在线调查问卷,以及来自印度的300名受访者的年龄、性别、教育程度等特征,使用雪球抽样技术收集的。这些特质的总分被计算为心理状态得分。采用比例/分数法和统计学检验对数据进行分析。新冠肺炎疫情对受访者的心理产生了负面影响。从研究中可以明显看出,在大流行期间,人们现有的紧张情绪对制造更多紧张情绪的影响。随机森林技术结果表明,热情、满意、热爱自然和宁静是影响人格状态得分的主要心理特征。通过卡方检验,发现被调查者的年龄、受教育程度、疫情前紧张情绪和疫情前紧张情绪影响疫情期间紧张情绪等特征对人格得分有统计学影响。优势比检验显示,具有PG学历的受访者在疫情期间保持良好心理状态的几率是受教育程度较低人群的4.62倍左右。男性保持良好心理状态的几率是女性的1.16倍。该研究揭示了COVID-19大流行对人们心理状态的负面影响,大多数人将其归因于大流行本身。
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引用次数: 0
Mental and Physical Symptoms of Alcohol Hangover 酒精宿醉的精神和身体症状
Pub Date : 2022-12-21 DOI: 10.58489/2836-8851/004
Gudisa Bereda
Alcohol hangover can be defined as the combination of mental and physical symptoms that are experienced the day after an episode of heavy alcohol drinking, launching when blood alcohol concentration approaches zero and characterized by the constellation of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. Significant changes observed on endocrine parameters (elevated concentrations of vasopressin, aldosterone, and renin) and metabolic acidosis (lowered blood potential hydrogen values due to elevated concentrations of lactate, ketone bodies, and free fatty acids) occurred during hangover and eventually causes dehydration and symptoms such as dry mouth and thirst. Females have more body fat and less water than men of the same body weight. Since alcohol is dispensed in body water, women reach higher blood alcohol concentrations levels than men despite consuming an identical number of alcohol units. Alcohol gets metabolized to an intermediate product, acetaldehyde, by the enzyme alcohol dehydrogenase, and then acetaldehyde is converted to acetate by a second enzyme aldehyde dehydrogenase. Acetaldehyde at higher concentrations causes toxic effects, such as rapid pulse, sweating, skin flushing, nausea, and vomiting. In most people, aldehyde dehydrogenase metabolizes acetaldehyde quickly and efficiently, so that this intermediate metabolite does not accumulate in high concentrations.
酒精宿醉可以定义为在大量饮酒后第二天出现的精神和身体症状的结合,在血液酒精浓度接近零时开始,以大量饮酒后出现的一系列不愉快的身体和精神症状为特征。在宿醉期间,内分泌参数(抗利尿激素、醛固酮和肾素浓度升高)和代谢性酸中毒(由于乳酸、酮体和游离脂肪酸浓度升高导致血氢电位降低)发生显著变化,并最终导致脱水和口干、口渴等症状。女性比相同体重的男性有更多的脂肪和更少的水。由于酒精溶于体内水分,尽管女性摄入的酒精单位数相同,但她们血液中的酒精浓度却高于男性。酒精通过酒精脱氢酶代谢成中间产物,乙醛,然后乙醛通过第二种醛脱氢酶转化成乙酸。高浓度的乙醛会引起毒性作用,如脉搏加快、出汗、皮肤发红、恶心和呕吐。在大多数人体内,乙醛脱氢酶能快速有效地代谢乙醛,因此这种中间代谢物不会高浓度积累。
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引用次数: 0
Comparative Analysis of Combination Therapy Regimens in Patients with Paranoid Schizophrenia with Non-Suicidal Auto aggression and Identified Signs of Resistance to Ongoing Neuroleptic Monotherapy 偏执型精神分裂症伴非自杀性自身攻击患者联合治疗方案的比较分析及对持续抗精神病药单一治疗的抗性迹象
Pub Date : 2022-12-21 DOI: 10.58489/2836-8851/005
Kravchenko I.V.
A comparative analysis of combination therapy regimens was carried out in patients with paranoid schizophrenia with NSAA and identified signs of resistance to ongoing neuroleptic monotherapy. In total, in the period from 2015 to 2022, 155 patients with paranoid schizophrenia with NSAA were studied as part of a multicenter randomized longitudinal study. It has been established that the first-line therapy regimen in this group of patients is a combined regimen of clozapine with haloperidol. Introduction. The increase in the number of therapeutically resistant patients with paranoid schizophrenia with auto aggression remains one of the most pressing problems in psychiatry remains as the most common nosological unit [1,2,3]. At the same time, a large amount of research material has been accumulated on the factors and conditions that affect the formation of the state of resistance in such patients [4,5,6,7]. First of all, these include: a debut at an early age, an "erased" beginning, a continuous course, the dominance of negative symptoms in the structure of the pathological process, and the fading of the affective component. A special place among the clinical predictors of therapeutic resistance is occupied by psychopathic disorders with auto aggressive tendencies, traditionally considered within the framework of heboid states. At the same time, until recently, the main drug from the group of neuroleptics used to overcome resistance was clozapine [8,9,10,11,12,13]. In practice, up to 30% of patients remain intact to its action, which dictates the need for combination therapy [14,15,16]. This predetermines the search for new schemes for the use of medicinal drugs to solve this problem.
对患有NSAA的偏执型精神分裂症患者进行了联合治疗方案的比较分析,并确定了对持续的抗精神病药单一治疗的抵抗迹象。在2015年至2022年期间,155例偏执型精神分裂症合并NSAA患者作为多中心随机纵向研究的一部分进行了研究。已经确定这组患者的一线治疗方案是氯氮平与氟哌啶醇的联合治疗方案。介绍。偏执型精神分裂症伴自身攻击的治疗抵抗患者数量的增加仍然是精神病学中最常见的疾病单元之一[1,2,3]。同时,对于影响该类患者耐药状态形成的因素和条件也积累了大量的研究资料[4,5,6,7]。首先,这些包括:幼年出道、“被抹去”的开端、持续的过程、病理过程结构中阴性症状的主导地位,以及情感成分的消退。在治疗抵抗的临床预测因子中,具有自我攻击倾向的精神疾病占据了一个特殊的位置,传统上被认为是在heboid状态的框架内。与此同时,直到最近,用于克服耐药的抗精神病药组中的主要药物是氯氮平[8,9,10,11,12,13]。在实践中,高达30%的患者对其作用完好无损,这表明需要联合治疗[14,15,16]。这预先决定了为解决这一问题而寻找新的药物使用方案。
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引用次数: 0
Innovation in Neurosurgery: Lessons Learned, Obstacles, and Potential Funding Sources 神经外科的创新:经验教训、障碍和潜在的资金来源
Pub Date : 2022-12-19 DOI: 10.1055/s-0043-1762321
C. Cutler, P. King, Majid Khan, Bankole Olowofela, B. Lucke-Wold
Innovation is central to neurosurgery and has dramatically increased over the last twenty years. Although the specialty innovates as a whole, only 3–4.7% of practicing neurosurgeons hold patents. Various roadblocks to innovation impede this process such as lack of understanding, increasing regulatory complexity, and lack of funding. Newly emerging technologies allow us to understand how to innovate and how to learn from other medical specialties. By further understanding the process of innovation, and the funding that supports it, Neurosurgery can continue to hold innovation as one of its’s central tenets.
创新是神经外科的核心,在过去的二十年里有了显著的增长。尽管整个专业都在创新,但只有3-4.7%的执业神经外科医生拥有专利。创新的各种障碍阻碍了这一进程,如缺乏理解、日益复杂的监管以及缺乏资金。新兴技术使我们懂得如何创新,以及如何向其他医学专业学习。通过进一步了解创新的过程,以及支持创新的资金,神经外科可以继续将创新作为其核心原则之一。
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引用次数: 0
Innovation in Neurosurgery: Lessons Learned, Obstacles, and Potential Funding Sources. 神经外科的创新:经验教训、障碍和潜在资金来源。
Pub Date : 2022-01-01 Epub Date: 2022-12-19
Christopher B Cutler, Patrick King, Majid Khan, Bankole Olowofela, Brandon Lucke-Wold

Innovation is central to neurosurgery and has dramatically increased over the last twenty years. Although the specialty innovates as a whole, only 3-4.7% of practicing neurosurgeons hold patents. Various roadblocks to innovation impede this process such as lack of understanding, increasing regulatory complexity, and lack of funding. Newly emerging technologies allow us to understand how to innovate and how to learn from other medical specialties. By further understanding the process of innovation, and the funding that supports it, Neurosurgery can continue to hold innovation as one of its's central tenets.

创新是神经外科的核心,并且在过去二十年中急剧增加。尽管神经外科作为一个整体不断创新,但只有 3-4.7% 的执业神经外科医生拥有专利。各种创新障碍阻碍了这一进程,例如缺乏了解、监管日益复杂以及缺乏资金。新兴技术让我们了解如何创新以及如何向其他医学专科学习。通过进一步了解创新过程和支持创新的资金,神经外科可以继续将创新作为其核心原则之一。
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引用次数: 0
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Neurons and neurological disorders
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