Platelet count and its indices-effectiveness in early diagnosis of neonatal sepsis

Priti Singh, V. Chandar
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Abstract

Context: Neonatal sepsis is the major cause of morbidity and mortality in developing countries requiring early diagnosis and treatment. The Gold standard Blood culture results are often delayed for 48 h with high false-negative values. Emerging evidence suggests that platelet indices such as plateletcrit, mean platelet volume (MPV), and platelet distribution width (PDW) are reliable biomarkers that are readily available while obtaining routine complete blood counts. Aim: The aim of the study was to evaluate the efficacy of platelet count (Platelets) and its indices in the early diagnosis of sepsis. Settings and Design: Blood samples were collected from all neonates admitted to the hospital with features of suspected sepsis. Materials and Methods: One hundred patients were recruited for this cross-sectional analytical prospective study. All neonates delivered in Himalayan Institute of Medical Sciences and those referred from outside with features of suspected septicemia meeting the inclusion criteria were taken for study purposes. Blood samples were collected at the time of admission. Patients were divided into three groups clinically suspected sepsis (probable sepsis), culture-positive sepsis, and culture-negative sepsis. Non-parametric tests like the Chi-square test were applied to see the association between the variables. The three groups were compared for Platelets and its indices with the Analysis of variance test. Results: MPV was 219.2, 174.8, and 205.7 (p<0.031), PDW 8.3, 12.5, and 11.5 (p<0.174) and MPV as 10.9, 9.94 and 11.9 (p<0.556) in probable sepsis, culture-positive and culture-negative sepsis, respectively. Conclusions: Platelets and its indices can be considered as a diagnostic tool for neonatal sepsis as it is cheap, rapid, and easily available and does not require additional equipment.
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血小板计数及其指标在新生儿脓毒症早期诊断中的作用
背景:新生儿败血症是发展中国家发病率和死亡率的主要原因,需要早期诊断和治疗。金标准血培养结果往往延迟48小时,假阴性值高。新出现的证据表明,血小板指数,如血小板电压、平均血小板体积(MPV)和血小板分布宽度(PDW)是可靠的生物标志物,在获得常规全血细胞计数时很容易获得。目的:探讨血小板计数及其指标在脓毒症早期诊断中的应用价值。设置和设计:采集所有疑似脓毒症入院新生儿的血液样本。材料和方法:本研究招募了100例患者进行横断面分析性前瞻性研究。所有在喜马拉雅医学科学研究所出生的新生儿和从外部转诊的具有疑似败血症特征的符合纳入标准的新生儿均被纳入研究。入院时采集血样。将患者分为临床怀疑脓毒症(可能脓毒症)、培养阳性脓毒症和培养阴性脓毒症三组。应用卡方检验等非参数检验来查看变量之间的关联。采用方差分析检验比较三组患者血小板及各项指标。结果:可能脓毒症、培养阳性和培养阴性脓毒症的MPV分别为219.2、174.8、205.7 (p<0.031), PDW分别为8.3、12.5、11.5 (p<0.174), MPV分别为10.9、9.94、11.9 (p<0.556)。结论:血小板及其指标可以作为新生儿败血症的诊断工具,因为它便宜、快速、容易获得,不需要额外的设备。
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