Safety assessment of useing Ba Kich dried extract for 28 days

Abstract

The “Ba kich” (Extractum Morinda ofcinalis) dried extract was evaluated for repeated dose toxicity at 28 days in rabbits. In a repeat dose toxicity test, rabbits were given oral solution of dry extract of Ba kich at the level of 0.2 g/kg and 1.0 g/kg for 28 days. Blood samples were taken on days 0, 14 and 28 to check biochemical and hematological parameters. Liver and kidney samples were obtained on day 28 for histopathology. The results of the 28-day repeated dose toxicity assessment showed that the dried Ba kich extract did not have a statistically significant effect on the biochemical and hematological indices, and did not cause damage to the histopathology of the kidney. However, dried Ba kich extract at both dose levels caused fatty degeneration and congestion in the liver of experimental rabbits.