EFFECT OF ETHYLENE OXIDE STERILIZATION ON PLASTISIZER MIGRATION AND MECHANICAL AND BLOOD PROPERTIES OF MEDICAL GRADE POLYVINYLE CHOLORIDE

IF 0.6 Q3 ENGINEERING, MULTIDISCIPLINARY IIUM Engineering Journal Pub Date : 2022-01-04 DOI:10.31436/iiumej.v23i1.1769

Maryam Poostchi, H. Bagheri

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Abstract

The use of phthalates as a plasticizer in plasticized polyvinyl chloride (PVC) always poses the threat of migration of phthalates into the environment through medical equipment. Phthalates can be used with natural-based plasticizers, such as Epoxidized soybean oil (ESBO) known as phthalate’s scavenger and PVC stabilizers. PVC formulations were characterized by different combinations of di (2-ethylhexyl) phthalate (DEHP) 30-40% with 5% ESBO. PVC flexibility increased significantly in the presence of ESBO, without a change in strength (tensile test). The decrease of the Tg temperature by adding ESBO in Differential Scanning Calorimetry indicated that ESBO preserved DEHP in the polymer. Also, it was shown that the sterilization process with Ethylene Oxide, similar to ESBO, decreased the Tg of polymer. DEHP migration was evaluated at a maximum level to the environment using the Gas Chromatography test. Samples containing ESBO showed less hemolysis. ABSTRAK: Penggunaan phthalates sebagai plasticizer dalam plastik polyvinyl chloride (PVC) selalu menimbulkan ancaman penghijrahan phthalates ke alam sekitar melalui peralatan perubatan. Phthalates boleh digunakan dengan plasticizer berasaskan semula jadi, seperti minyak kacang soya Epoxidized (ESBO) yang dikenali sebagai pemulung phthalate dan penstabil PVC. Formulasi PVC dicirikan oleh kombinasi yang berbeza di (2-ethylhexyl) phthalate (DEHP) 30-40% dengan 5% ESBO. Fleksibiliti PVC meningkat dengan ketara di hadapan ESBO, tanpa perubahan kekuatan (ujian tegangan). Penurunan suhu Tg dengan menambahkan ESBO dalam Calorimetri Pengimbasan Berbeza menunjukkan bahawa ESBO mengekalkan DEHP dalam polimer. Juga, ditunjukkan bahawa proses pensterilan dengan Etilena Oksida, serupa dengan ESBO, menurunkan Tg polimer. Penghijrahan DEHP dinilai pada tahap maksimum ke lingkungan menggunakan uji Kromatografi Gas. Sampel yang mengandungi ESBO menunjukkan kurang hemolisis.

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环氧乙烷灭菌对医用级聚氯乙烯增塑剂迁移及力学性能和血液性能的影响

在增塑型聚氯乙烯(PVC)中使用邻苯二甲酸盐作为增塑剂总是会造成邻苯二甲酸盐通过医疗设备迁移到环境中的威胁。邻苯二甲酸酯可以与天然增塑剂一起使用，如环氧大豆油(ESBO)，被称为邻苯二甲酸酯的清除剂和PVC稳定剂。PVC配方采用邻苯二甲酸二(2-乙基己基)酯(DEHP) 30-40%和5% ESBO的不同组合进行表征。在ESBO的存在下，PVC的柔韧性显著增加，而强度没有变化(拉伸试验)。差示扫描量热法中加入ESBO降低了Tg温度，表明ESBO保留了聚合物中的DEHP。结果表明，环氧乙烷灭菌过程与ESBO灭菌过程相似，降低了聚合物的Tg。使用气相色谱法测试评估DEHP迁移到环境的最大水平。含有ESBO的样品溶血较少。摘要:彭家南邻苯二甲酸盐增塑剂聚氯乙烯(PVC)可塑性和可塑性:彭家南邻苯二甲酸盐可塑性和可塑性。邻苯二甲酸乙酯类增塑剂，环氧化(ESBO)，邻苯二甲酸乙酯类聚氯乙烯。配方:聚氯乙烯(二乙基己基)邻苯二甲酸酯(DEHP) 30-40%登甘5% ESBO。弹性聚氯乙烯(PVC)脑膜革(PVC)脑膜革(PVC)脑膜革(PVC)脑膜革(PVC)Penurunan suhu Tg dengan mengekalkan DEHP dalam聚合物Juga, ditunjukkan bahawa处理pensterilan dengan Etilena Oksida, serupa dengan ESBO, menurunkan Tg聚合物。Penghijrahan DEHP dinilai pada tahap maksimum ke lingkungan menggunakan uji Kromatografi Gas。Sampel yang mengandungi ESBO menunjukkan kurang溶血。

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来源期刊

IIUM Engineering Journal ENGINEERING, MULTIDISCIPLINARY-

CiteScore

2.10

自引率

20.00%

发文量

审稿时长

40 weeks

期刊介绍： The IIUM Engineering Journal, published biannually (June and December), is a peer-reviewed open-access journal of the Faculty of Engineering, International Islamic University Malaysia (IIUM). The IIUM Engineering Journal publishes original research findings as regular papers, review papers (by invitation). The Journal provides a platform for Engineers, Researchers, Academicians, and Practitioners who are highly motivated in contributing to the Engineering disciplines, and Applied Sciences. It also welcomes contributions that address solutions to the specific challenges of the developing world, and address science and technology issues from an Islamic and multidisciplinary perspective. Subject areas suitable for publication are as follows: -Chemical and Biotechnology Engineering -Civil and Environmental Engineering -Computer Science and Information Technology -Electrical, Computer, and Communications Engineering -Engineering Mathematics and Applied Science -Materials and Manufacturing Engineering -Mechanical and Aerospace Engineering -Mechatronics and Automation Engineering