MIR-21 regulating distribution of intestinal flora through TNF-α promotes progression of ulcerative colitis.

Q2 Nursing Texto Contexto Enfermagem Pub Date : 2024-04-23 DOI:10.5937/jomb0-43320

Yang Ke, Xueni Liu, Tao Niu, Zhao Qiang, Feng Gao

引用次数: 0

Abstract

Background: To study the changes in intestinal flora in patients with ulcerative colitis (UC), and to explore its correlations with micro ribonucleic acid (miR)-21 and serum tumor necrosis factor-a (TNF-α).

Methods: A total of 150 patients with UC were selected and divided into remission group and seizure group according to the severity of disease. At the same time, 150 healthy people receiving physical examination in the hospital during the same period were selected as control group. The levels of fecal miR-21 and TNF-α in all subjects were determined via reverse transcription-polymerase chain reaction (RT-PCR). The correlation between miR-21 and TNF-α and their associations with the changes in intestinal bacteria in UC were analyzed using Pearson correlation analysis. The risk factors affecting the occurrence of UC were explored via multivariate logistic regression analysis.

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MIR-21 通过 TNF-α 调节肠道菌群的分布，促进溃疡性结肠炎的发展。

研究背景研究溃疡性结肠炎（UC）患者肠道菌群的变化，并探讨其与微核糖核酸（miR）-21和血清肿瘤坏死因子-a（TNF-α）的相关性：方法：选取 150 名 UC 患者，根据病情严重程度分为缓解组和发作组。同时选择同期在医院接受体检的 150 名健康人作为对照组。通过反转录聚合酶链反应（RT-PCR）测定所有受试者粪便中 miR-21 和 TNF-α 的水平。采用皮尔逊相关分析法分析了 miR-21 和 TNF-α 的相关性及其与 UC 肠道细菌变化的关系。通过多变量逻辑回归分析探讨了影响 UC 发生的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Texto Contexto Enfermagem Nursing-General Nursing

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Texto & Contexto Enfermagem provides space for reflection and deepening of knowledge about issues of practice, teaching and research in health and nursing, at national and international levels. The journal is published quarterly in the rolling pass or Continuous flow mode, accepting manuscripts in Portuguese, English or Spanish, in the categories original article, reflection, experience report and review. Contributions designated to the dissemination of unpublished original research results are prioritized for publication. Special issues are published at the discretion of the Board of Directors and Associate Editors. All manuscripts are published in two versions, one of which is English, aiming to cover the largest number of readers worldwide. The editorial policy of Texto & Contexto Enfermagem is based on rigorous quality criteria for indexing and publishing (including technical and normative aspects, graphic and textual quality and excellence in scientific content); on responsibility for shared management between the Board of Directors, Editorial Board and Internal and External Editors Associates; and on the rigorous and constructive peer review, preserving the anonymity of authors and reviewers (double blinded).