SARS-CoV-2 Omicron variants BA.1 and BA.2 both show similarly reduced disease severity of COVID-19 compared to Delta, Germany, 2021 to 2022.

Claudia Sievers, Benedikt Zacher, Alexander Ullrich, Matthew Huska, Stephan Fuchs, Silke Buda, Walter Haas, Michaela Diercke, Matthias An der Heiden, Stefan Kröger
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Abstract

German national surveillance data analysis shows that hospitalisation odds associated with Omicron lineage BA.1 or BA.2 infections are up to 80% lower than with Delta infection, primarily in ≥ 35-year-olds. Hospitalised vaccinated Omicron cases' proportions (2.3% for both lineages) seemed lower than those of the unvaccinated (4.4% for both lineages). Independent of vaccination status, the hospitalisation frequency among cases with Delta seemed nearly threefold higher (8.3%) than with Omicron (3.0% for both lineages), suggesting that Omicron inherently causes less severe disease.

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与德国 2021 年至 2022 年的德尔塔相比,SARS-CoV-2 Omicron 变体 BA.1 和 BA.2 都显示 COVID-19 的疾病严重程度同样有所降低。
德国国家监测数据分析显示,与感染德尔塔病毒相比,感染奥米克龙BA.1或BA.2系的住院几率最多可降低80%,主要发生在年龄≥35岁的人群中。已接种疫苗的奥米克龙病例的住院比例(两种血统均为 2.3%)似乎低于未接种疫苗的病例(两种血统均为 4.4%)。与疫苗接种情况无关,接种德尔塔疫苗的病例的住院频率(8.3%)似乎比接种奥米克龙疫苗的病例(两种血统均为 3.0%)高出近三倍,这表明奥米克龙疫苗本身引起的疾病较轻。
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