Tjb Kabongo, LA Luvingisa, MP Ngoie, M. Musuyu, M. Musunga, MW Kabamba, PP Pyana
{"title":"Evaluation of the toxicity of aqueous extracts of Aframomum melegueta, Picralima nitida, and Garcinia cola in Wistar rats","authors":"Tjb Kabongo, LA Luvingisa, MP Ngoie, M. Musuyu, M. Musunga, MW Kabamba, PP Pyana","doi":"10.17352/ojbs.000035","DOIUrl":null,"url":null,"abstract":"In order to determine the risks to human health associated with the use of certain medicinal plants, including Aframomum melegueta, Garcinia kola and Picralima nitida in a preclinical evaluation of the resistance, a pool of these three aqueous extracts was given once daily for ten days by gavage in Wistar rats. Haematological and biochemical analyzes after oral administration revealed a decrease in certain hepatic biomarkers such as glucose, Alanine Aminotransferase (ALT), etc., and renal biomarkers such as urea, creatinine, and creatinine kinase); increase in certain biomarkers such as Aspartate Transaminase (AST), an indicator of kidney and liver capacity.","PeriodicalId":19569,"journal":{"name":"Open Journal of Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Journal of Biological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17352/ojbs.000035","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In order to determine the risks to human health associated with the use of certain medicinal plants, including Aframomum melegueta, Garcinia kola and Picralima nitida in a preclinical evaluation of the resistance, a pool of these three aqueous extracts was given once daily for ten days by gavage in Wistar rats. Haematological and biochemical analyzes after oral administration revealed a decrease in certain hepatic biomarkers such as glucose, Alanine Aminotransferase (ALT), etc., and renal biomarkers such as urea, creatinine, and creatinine kinase); increase in certain biomarkers such as Aspartate Transaminase (AST), an indicator of kidney and liver capacity.
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