Analisis Sensitivitas Dan Spesifisitas COVID-19 Ag Rapid Test Terhadap PCR Test

Wisnu Murti, D. R. Wijayanti, Wulan Fitriani Safari
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Abstract

SARS-Cov-2 is the newest coronavirus caused Covid-19 which can infect human and pandemic, COVID-19 parameter testing can be done with serological tests used to detect antibody or antigen and also molecular test using PCR method. This research is aimed to compare the sensitivity and specificity between COVID-19 Ag rapid test and PCR test. This research is an analytical descriptive study with 421 samples were obtained from documentation study with probability systematic random sampling and by using secondary data taken from Laboratory Information System (LIS) at Siloam Hospitals Lippo Village Tangerang and the type of observational analytical research with cross sectional design. The analysis results show the sensitivity rate was 96.64%, specificity was 93.75%, PPV was 89.44%, NPV was 98.08%, LR (+) was 15.46, and LR (-) was 0.04. The conclusion of the research result, COVID-19 Ag rapid test is valid to be used as a diagnostic test because it has high rate of sensitivity and specificity according to WHO regulations.   
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PCR测试的COVID-19 Ag快速测试和特异性分析
SARS-Cov-2是最新的冠状病毒引起的Covid-19,可感染人类并大流行,Covid-19参数检测可通过血清学检测进行抗体或抗原检测,也可采用PCR方法进行分子检测。本研究旨在比较COVID-19抗原快速检测与PCR检测的敏感性和特异性。本研究是一项分析性描述性研究,采用概率系统随机抽样的文献研究和从西罗亚医院实验室信息系统(LIS)获取的二次数据,采用横断面设计的观察性分析研究。分析结果显示,敏感性为96.64%,特异性为93.75%,PPV为89.44%,NPV为98.08%,LR(+)为15.46,LR(-)为0.04。研究结果表明,根据世界卫生组织的规定,COVID-19抗原快速检测具有较高的敏感性和特异性,可作为一种有效的诊断方法。
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