Are Altered Expression of Vascular Endothelial Growth Factor and Placental Growth Factor Associated with Placental Angiogenesis in Recurrent Pregnancy Loss?

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Indian Journal of Clinical Biochemistry Pub Date : 2024-07-01 Epub Date: 2023-02-09 DOI:10.1007/s12291-023-01117-4

Shehnaz Sultana, M R Renjini Devi, Mahesh Kumar Rathod, Penagaluru Pardhanandana Reddy, Venkateshwari Ananthapur

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Abstract

Angiogenesis is one of the most important steps during pregnancy for placental and fetal development. Based on the hypothesis that vascular insufficiency and altered angiogenesis may lead to early pregnancy loss, the present study was aimed to understand the role of Vascular endothelial growth factor (VEGFA) and Placental growth factor (PLGF) gene expression in placental angiogenesis in the pathogenesis of Recurrent pregnancy loss (RPL). Gene expression analysis of VEGFA and PLGF was carried out in the placental tissue collected from 30 women with recurrent pregnancy loss and compared with the placenta obtained from 16 women with medically terminated pregnancy. The mRNA expression of both VEGFA and PLGF genes were significantly downregulated in the placenta of recurrent pregnancy loss in comparison to the placenta of medically terminated pregnancies. In conclusion the results of the present study suggest that altered expression of VEGFA and PLGF genes in placenta disturb the angiogenesis and contribute to the pathogenesis of recurrent pregnancy loss.

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血管内皮生长因子和胎盘生长因子的表达改变与复发性妊娠失败中的胎盘血管生成有关吗？

血管生成是孕期胎盘和胎儿发育最重要的步骤之一。基于血管功能不全和血管生成改变可能导致早期妊娠失败的假设，本研究旨在了解血管内皮生长因子（VEGFA）和胎盘生长因子（PLGF）基因表达在胎盘血管生成中的作用，以及复发性妊娠失败（RPL）的发病机制。研究人员对 30 名复发性妊娠丢失妇女的胎盘组织进行了血管内皮生长因子（VEGFA）和胎盘生长因子（PLGF）基因表达分析，并与 16 名药物终止妊娠妇女的胎盘进行了比较。与药物终止妊娠的胎盘相比，复发性妊娠流产的胎盘中 VEGFA 和 PLGF 基因的 mRNA 表达均显著下调。总之，本研究结果表明，胎盘中VEGFA和PLGF基因表达的改变会干扰血管生成，并导致复发性妊娠失败的发病机制。

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来源期刊

Indian Journal of Clinical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

4.50

自引率

4.80%

发文量

期刊介绍： The primary mission of the journal is to promote improvement in the health and well-being of community through the development and practice of clinical biochemistry and dissemination of knowledge and recent advances in this discipline among professionals, diagnostics industry, government and non-government organizations. Indian Journal of Clinical Biochemistry (IJCB) publishes peer reviewed articles that contribute to the existing knowledge in all fields of Clinical biochemistry, either experimental or theoretical, particularly deal with the applications of biochemistry, molecular biology, genetics, biotechnology, and immunology to the diagnosis, treatment, monitoring and prevention of human diseases. The articles published also include those covering the analytical and molecular diagnostic techniques, instrumentation, data processing, quality assurance and accreditation aspects of the clinical investigations in which chemistry has played a major role, or laboratory animal studies with biochemical and clinical relevance.