The significance of biomarkers of inflammation in predicting the activity of Lupus nephritis.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Medical Biochemistry Pub Date : 2024-01-25 DOI:10.5937/jomb0-43457

Violeta Rabrenović, Milica Petrović, Milorad Rabrenović, Dejan Pilčević, Nemanja Rančić

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Abstract

Background: Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE). There are increased studies examining the role of different markers that would facilitate diagnosis, LN activity monitoring, relapse occurrence, and the right time to introduce maintenance therapy. We aimed to examine the importance of determining the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immuneinflammatory index (SII) and systemic inflammatory response index (SIRI) in LN, comparing their significance with other standard parameters of active disease.

Methods: The clinical examination included 66 patients (34 with active and 32 with LN in remission) and 23 healthy controls. The investigated parameters were CRP, CBC, creatinine, albumin, GFR, C3, C4, ANA, anti-ds DNA Ab, in urine: sediment analysis, SLEDAI/r, proteinuria 24h and Up/cre. We determined the derived markers: NLR, PLR, SIRI, and SII and their correlation with other parameters of active disease.

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炎症生物标志物在预测狼疮性肾炎活动性方面的意义。

背景：狼疮性肾炎（LN）是系统性红斑狼疮（SLE）最严重的表现之一。目前有越来越多的研究在探讨不同标记物的作用，这些标记物有助于诊断、LN活动监测、复发发生以及采用维持治疗的正确时机。我们旨在研究确定中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）在 LN 中的重要性，并比较它们与其他活动性疾病标准参数的意义：临床检查包括 66 名患者（34 名活动期 LN 患者和 32 名缓解期 LN 患者）和 23 名健康对照组。检查指标包括 CRP、CBC、肌酐、白蛋白、GFR、C3、C4、ANA、抗ds DNA Ab，尿液指标包括沉淀物分析、SLEDAI/r、24 小时蛋白尿和 Up/cre。我们还测定了衍生标记物：NLR、PLR、SIRI 和 SII，以及它们与其他活动性疾病参数的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.