Giant congenital melanocytic nevus and malignant transforation: a case report and literature review

Abstract

Objective To investigate the diagnosis and differential diagnosis of malignant transformation in children with giant congenital melanocyte nevus (GCMN). Methods The clinical features and results of various auxiliary examinations (including imaging and laboratory) from one GCMN child treated in the First Affiliated Hospital of Zhengzhou University in July 2017 were retrospectively analyzed. And related literature was reviewed. Results Results of imaging, pathology, bone marrow cytology, immunohistochemistry, flow cytology and other examinations and clinical symptoms were synthetically considered. As a result, this case was diagnosed with malignant GCMN with hepatic and bone-marrow metastases. Conclusions The diagnosis of bone marrow metastasis of malignant melanoma mainly depends on the morphological examination of bone marrow biopsy smear. The definite diagnosis of bone marrow metastasis of malignant melanoma depends on the comprehensive analysis of clinical symptoms, pathological diagnosis, cell morphology and cytochemical staining. Key words: Giant congenital melanocytic nevus; Bone marrow cytology; Pathology