{"title":"Metformin with insulin does not improve the glycaemic control of overweight/obese adolescents with type 1 diabetes","authors":"A. Lucas-Herald, K. Robertson","doi":"10.1136/archdischild-2016-312326","DOIUrl":null,"url":null,"abstract":"Design: Placebo-controlled randomised controlled trial.\n\nAllocation: Via computer generated sequence.\n\nBlinding: Double-blind.\n\nSetting: 26 paediatric endocrinology clinics in the Type 1 Diabetes Exchange Clinic Network between 2013 and 2014.\n\nPatients: 140 adolescents aged between 12.1 and 19.6 years (mean (SD) 15.3 (1.7)) with type 1 diabetes for >1 year and a body mass index >85th centile for age, total daily insulin dose >0.8 units/kg and three times daily self-monitoring of blood glucose.\n\nIntervention : 2000 mg daily dose metformin compared with placebo.\n\nOutcomes : Primary outcome: change in haemoglobin A1c (HbA1c) from baseline to 26 weeks. Prespecified secondary outcomes: total daily dose (TDD) insulin per kg body weight, total basal insulin per kg body weight, anthropometry, blood pressure, metabolic profile.\n\nFollow-up period …","PeriodicalId":8153,"journal":{"name":"Archives of Disease in Childhood: Education & Practice Edition","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Disease in Childhood: Education & Practice Edition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/archdischild-2016-312326","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Design: Placebo-controlled randomised controlled trial.
Allocation: Via computer generated sequence.
Blinding: Double-blind.
Setting: 26 paediatric endocrinology clinics in the Type 1 Diabetes Exchange Clinic Network between 2013 and 2014.
Patients: 140 adolescents aged between 12.1 and 19.6 years (mean (SD) 15.3 (1.7)) with type 1 diabetes for >1 year and a body mass index >85th centile for age, total daily insulin dose >0.8 units/kg and three times daily self-monitoring of blood glucose.
Intervention : 2000 mg daily dose metformin compared with placebo.
Outcomes : Primary outcome: change in haemoglobin A1c (HbA1c) from baseline to 26 weeks. Prespecified secondary outcomes: total daily dose (TDD) insulin per kg body weight, total basal insulin per kg body weight, anthropometry, blood pressure, metabolic profile.
Follow-up period …
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