A Review on Fluconazole

Abstract

The improvement of a significant dissolution manner for drug merchandise with restrained water solubility has been a project to the pharmaceutical industry. fluconazole (BCS Class 1 drug) is an anti-fungal drug. There isn't any reputable dissolution medium to be had withinside the literature. In the prevailing study, parameters inclusive of solubility, medium pH, surfactant type, dissolution behaviour of formulations, impact of sink situations, stability, and discriminatory impact of dissolution checking out had been studied for the choice of a right dissolution medium. Results of solubility facts found out that solubility elevated with a growth in pH. The drug and advertised formulations had been strong withinside the dissolution media used. An agitation velocity of fifty rpm confirmed a greater discriminating drug launch profile than seventy-five rpm. The discriminating dissolution technique for fluconazole components is paddle at 50 rpm, 900 mL pH 6.8 phosphate buffer, more than 80% of the label quantity is launched over 60 minutes.