Spectrophotometric method development and validation for atorvastatin calcium and nifedipine HCl in bulk and tablet dosage form using absorption ratio method assay of atorvastatin and nifedipine

Journal of Pharmacy Research Pub Date : 2013-07-01 DOI:10.1016/j.jopr.2013.07.012

Sathis Kumar Dinakaran , Babitha Alluri , Koushik Reddy Annareddy , VijayaSravani Ayyagari , Harani Avasarala , Ravishankar Kakaraparthy , Pavan Kumar Chintamaneni , Raja Gadi

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引用次数: 6

Abstract

Objectives

A simple, economic, accurate Absorption ratio method was developed for the simultaneous estimation of atorvastatin calcium and nifedipine HCl in bulk and tablet dosage form.

Method

Methanol was used as a diluent. The absorptions were observed at 237 nm and 297 nm which were selected based on overlap spectra of atorvastatin calcium and nifedipine HCl.

Results and conclusion

The linearity range was found to be 6–10 μg/ml. The proposed method was validated. The reports was expressed that the proposed method was found to be simple, precise, accurate and rapid for the simultaneous estimation of atorvastatin calcium and nifedipine HCl in bulk and tablet dosage form using absorption ratio method.

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利用吸收比法测定阿托伐他汀和硝苯地平原料药和片剂中的钙和硝苯地平

目的建立一种简便、经济、准确的阿托伐他汀钙和硝苯地平片剂同时测定的吸收比方法。方法采用甲醇作为稀释剂。根据阿托伐他汀钙和硝苯地平的重叠光谱选择237 nm和297 nm的吸光度。结果与结论在6 ~ 10 μg/ml范围内呈线性关系。对所提方法进行了验证。结果表明，该方法简便、准确、快速，适用于用吸收比法同时测定原料药和片剂中阿托伐他汀钙和硝苯地平的含量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Pharmacy Research

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