Mechanisms of Wnt signaling and control.

Stephanie Grainger, Karl Willert
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引用次数: 69

Abstract

The Wnt signaling pathway is a highly conserved system that regulates complex biological processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to break symmetry and provide cells with positional information that is critical to the patterning of the entire body plan. At the organismal level, Wnt signals are employed to orchestrate fundamental developmental processes, including the specification of the anterior-posterior body axis, induction of the primitive streak and ensuing gastrulation movements, and the generation of cell and tissue diversity. Wnt functions extend into adulthood where they regulate stem cell behavior, tissue homeostasis, and damage repair. Disruption of Wnt signaling activity during embryonic development or in adults results in a spectrum of abnormalities and diseases, including cancer. The molecular mechanisms that underlie the myriad of Wnt-regulated biological effects have been the subject of intense research for over three decades. This review is intended to summarize our current understanding of how Wnt signals are generated and interpreted. This article is categorized under: Biological Mechanisms > Cell Signaling Developmental Biology > Stem Cell Biology and Regeneration.

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Wnt信号和控制的机制。
Wnt信号通路是一个高度保守的系统,在所有后生动物物种中调节复杂的生物过程。在细胞水平上,分泌的Wnt蛋白打破对称性,为细胞提供位置信息,这对整个身体平面的模式至关重要。在机体水平上,Wnt信号被用于协调基本的发育过程,包括前后体轴的规范,原始条纹的诱导和随后的原肠胚运动,以及细胞和组织多样性的产生。Wnt的功能延伸到成年期,调节干细胞行为、组织稳态和损伤修复。在胚胎发育或成人中,Wnt信号活动的中断会导致一系列异常和疾病,包括癌症。三十多年来,wnt调控的生物效应背后的分子机制一直是人们深入研究的主题。这篇综述旨在总结我们目前对Wnt信号如何产生和解释的理解。本文分类如下:生物学机制>细胞信号传导发育生物学>干细胞生物学与再生。
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来源期刊
CiteScore
18.40
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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