Increased Serum Sodium at Acute Kidney Injury Onset Predicts In-Hospital Death.

Benedikt Marahrens, Leah Damsch, Rebecca Lehmann, Igor Matyukhin, Susann Patschan, Daniel Patschan
{"title":"Increased Serum Sodium at Acute Kidney Injury Onset Predicts In-Hospital Death.","authors":"Benedikt Marahrens, Leah Damsch, Rebecca Lehmann, Igor Matyukhin, Susann Patschan, Daniel Patschan","doi":"10.14740/jocmr4845","DOIUrl":null,"url":null,"abstract":"Background Over the last decades, acute kidney injury (AKI) has been identified as a potentially fatal diagnosis which substantially increases in-hospital mortality in the short term and morbidity/mortality in the long term. However, reliable biomarkers for predicting AKI-associated outcomes are still missing. In this study, we assessed whether serum sodium, measured at different time points during the in-hospital treatment period, provided prognostic information in AKI. Methods This was a retrospective, observational cohort study. AKI subjects were identified via the in-hospital AKI alert system. Serum sodium and potassium levels were documented at five pre-defined time points: hospital admission, AKI onset, minimum estimated glomerular filtration rate, minimum and maximum of the respective electrolyte during the treatment period. In-hospital death, the need for kidney replacement therapy (KRT) and recovery of kidney function were defined as endpoints. Results Patients who suffered in-hospital death (n = 37, 23.1%) showed significantly higher serum sodium levels at diagnosis of AKI (survivors: 145.7 ± 2.13 vs. non-survivors: 138.8 ± 0.636 mmol/L, P = 0.003). A logistic regression model was significant for serum sodium levels in patients with in-hospital death (X2, P = 0.003; odds ratio = 1.08 (1.022 - 1.141); R2 = 0.082; d = 0.089). This suggests an increase of the relative risk for in-hospital death by 8% with every unit of serum sodium increase. Patients with a sodium above the upper normal range at AKI diagnosis were also more likely to suffer in-hospital death (P = 0.001). Conclusion In summary, we present evidence that serum sodium, measured at time of AKI diagnosis, potentially serves as a predictor for in-hospital death in patients with AKI.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"15 2","pages":"90-98"},"PeriodicalIF":0.0000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/91/jocmr-15-090.PMC9990719.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Medicine Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/jocmr4845","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Background Over the last decades, acute kidney injury (AKI) has been identified as a potentially fatal diagnosis which substantially increases in-hospital mortality in the short term and morbidity/mortality in the long term. However, reliable biomarkers for predicting AKI-associated outcomes are still missing. In this study, we assessed whether serum sodium, measured at different time points during the in-hospital treatment period, provided prognostic information in AKI. Methods This was a retrospective, observational cohort study. AKI subjects were identified via the in-hospital AKI alert system. Serum sodium and potassium levels were documented at five pre-defined time points: hospital admission, AKI onset, minimum estimated glomerular filtration rate, minimum and maximum of the respective electrolyte during the treatment period. In-hospital death, the need for kidney replacement therapy (KRT) and recovery of kidney function were defined as endpoints. Results Patients who suffered in-hospital death (n = 37, 23.1%) showed significantly higher serum sodium levels at diagnosis of AKI (survivors: 145.7 ± 2.13 vs. non-survivors: 138.8 ± 0.636 mmol/L, P = 0.003). A logistic regression model was significant for serum sodium levels in patients with in-hospital death (X2, P = 0.003; odds ratio = 1.08 (1.022 - 1.141); R2 = 0.082; d = 0.089). This suggests an increase of the relative risk for in-hospital death by 8% with every unit of serum sodium increase. Patients with a sodium above the upper normal range at AKI diagnosis were also more likely to suffer in-hospital death (P = 0.001). Conclusion In summary, we present evidence that serum sodium, measured at time of AKI diagnosis, potentially serves as a predictor for in-hospital death in patients with AKI.

Abstract Image

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
急性肾损伤发病时血清钠升高预测院内死亡
背景:在过去的几十年里,急性肾损伤(AKI)已被确定为一种潜在的致命诊断,它在短期内显著增加住院死亡率和长期发病率/死亡率。然而,预测aki相关结果的可靠生物标志物仍然缺失。在这项研究中,我们评估了在住院治疗期间不同时间点测量的血清钠是否能提供AKI的预后信息。方法:这是一项回顾性、观察性队列研究。通过院内AKI警报系统识别AKI受试者。在五个预先定义的时间点记录血清钠和钾水平:入院、AKI发病、肾小球滤过率最小估计值、治疗期间各自电解质的最小和最大值。将院内死亡、肾脏替代治疗(KRT)需求和肾功能恢复定义为终点。结果:住院死亡患者(n = 37, 23.1%)在AKI诊断时血清钠水平显著升高(幸存者:145.7±2.13 vs非幸存者:138.8±0.636 mmol/L, P = 0.003)。logistic回归模型对院内死亡患者的血清钠水平有显著性影响(X2, P = 0.003;优势比= 1.08 (1.022 - 1.141);R2 = 0.082;D = 0.089)。这表明,每增加一个单位血清钠,住院死亡的相对风险增加8%。在AKI诊断时钠高于正常上限范围的患者也更容易发生院内死亡(P = 0.001)。结论:总之,我们提供的证据表明,在AKI诊断时测量的血清钠可能作为AKI患者住院死亡的预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The Effect of Preventive Care and Rehabilitation Nursing on Elderly Hypertension Meta-analysis of In-stent Restenosis Factors after Coronary Intervention Effect of Dietary Carotenoids and Lutein on Eye Health Maintenance in Elderly People One Case of Solar Dermatitis Treated with Umbilical Needle "Four Positions" Combined with Body Acupuncture Primary Presacral Neuroendocrine Tumors Presented by Lumbosacral Pain: a Case Report
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1