Therapeutic in vivo synthetic chemistry using an artificial metalloenzyme with glycosylated human serum albumin.

Kenshiro Yamada, Kyohei Muguruma, Katsunori Tanaka
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Abstract

The concept of "therapeutic in vivo synthetic chemistry" refers to chemical synthesis in living systems using new-to-nature reactions for the treatment or diagnosis of diseases. This review summarizes our development of therapeutic in vivo synthetic chemistry using glycan-modified human serum albumin (glycoHSA) and utilizing the selective glycan-targeting and metal protective effects of metal catalysts. The four artificial metalloenzymes with glycoHSA provided good cancer treatment results based on on-site drug synthesis and selective cell-tagging strategies. Thus, we propose that therapeutic in vivo synthetic chemistry using glycoHSA as a new modality of therapy or diagnosis is applicable to a wide range of diseases.

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用糖基化人血清白蛋白的人工金属酶进行治疗性体内合成化学。
“治疗性体内合成化学”的概念是指在生命系统中利用新的自然反应进行化学合成,以治疗或诊断疾病。本文综述了利用糖聚糖修饰的人血清白蛋白(glycoHSA),利用金属催化剂的选择性靶向和金属保护作用,在治疗性体内合成化学方面的研究进展。基于原位药物合成和选择性细胞标记策略,四种含糖hsa的人工金属酶提供了良好的肿瘤治疗效果。因此,我们建议使用糖蛋白sa作为一种新的治疗或诊断方式的体内合成化学治疗适用于广泛的疾病。
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来源期刊
Advances in carbohydrate chemistry and biochemistry
Advances in carbohydrate chemistry and biochemistry 生物-生化与分子生物学
CiteScore
2.20
自引率
0.00%
发文量
0
期刊介绍: Advances in Carbohydrate Chemistry and Biochemistry has provided, since its inception in 1945, critical and informative articles written by research specialists that integrate the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology to the study of carbohydrates. Its articles present a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.
期刊最新文献
Towards one-pot selective synthesis of cyclic oligosaccharides. Pseudo-glycoconjugates with a C-glycoside linkage. Conformationally restricted donors for stereoselective glycosylation. Boron-mediated aglycon delivery (BMAD) for the stereoselective synthesis of 1,2-cis glycosides. Therapeutic in vivo synthetic chemistry using an artificial metalloenzyme with glycosylated human serum albumin.
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